Role of altered mitochondria functions in the pathogenesis of systemic lupus erythematosus

Mitochondria, main producers of reactive-oxygen species (ROS), were studied to examine their role in the pathogenesis of systemic lupus erythematosus (SLE). PBMCs and mitochondria were isolated from SLE patients and healthy volunteers for various parameters. Mitochondrial ROS, swelling, hyperpolariz...

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Veröffentlicht in:	Lupus 2016-03, Vol.25 (3), p.272-281
Hauptverfasser:	Leishangthem, B D, Sharma, A, Bhatnagar, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Apoptosis Case-Control Studies Caspase 3 - analysis Cytochromes c - analysis Electron Transport Chain Complex Proteins - analysis Female Humans Leukocytes, Mononuclear - enzymology Leukocytes, Mononuclear - pathology Lupus Erythematosus, Systemic - diagnosis Lupus Erythematosus, Systemic - enzymology Lupus Erythematosus, Systemic - pathology Membrane Potential, Mitochondrial Mitochondria - enzymology Mitochondria - pathology Mitochondrial Diseases - diagnosis Mitochondrial Diseases - enzymology Mitochondrial Diseases - pathology Mitochondrial Swelling Reactive Oxygen Species - analysis
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Zusammenfassung:	Mitochondria, main producers of reactive-oxygen species (ROS), were studied to examine their role in the pathogenesis of systemic lupus erythematosus (SLE). PBMCs and mitochondria were isolated from SLE patients and healthy volunteers for various parameters. Mitochondrial ROS, swelling, hyperpolarization and levels of cytochrome c, caspase3 in the cells were assessed by flow cytometry. ROS was significantly increased in SLE patients (SLE vs controls: 1.83 ± 1.03 vs 1.10 ± 0.35; p
ISSN:	0961-2033 1477-0962
DOI:	10.1177/0961203315605370