DNA methylation, histone acetylation and methylation of epigenetic modifications as a therapeutic approach for cancers

Highlights • This review summarizes the roles of epigenetic modification. • Epigenetic modification connects gene regulation, cancer, sugar metabolism, ROS, carcinogenesis, and therapeutic targets. • We discuss the combined treatment of epigenetic regulator and cancer therapy. • We highlight ongoing...

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Veröffentlicht in:	Cancer letters 2016-04, Vol.373 (2), p.185-192
Hauptverfasser:	Yen, Ching-Yu, Huang, Hurng-Wern, Shu, Chih-Wen, Hou, Ming-Feng, Yuan, Shyng-Shiou F, Wang, Hui-Ru, Chang, Yung-Ting, Farooqi, Ammad Ahmad, Tang, Jen-Yang, Chang, Hsueh-Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Animals Autophagy Breast cancer Cancer therapies Carbohydrate Metabolism Chromatin DNA Methylation Epigenesis, Genetic Epigenetic modification Glycolysis - drug effects Hematology, Oncology and Palliative Medicine Histone Histones - metabolism Humans Methylation Mutation Neoplasms - drug therapy Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Oxidative Stress Sugar metabolism
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Beschreibung
Zusammenfassung:	Highlights • This review summarizes the roles of epigenetic modification. • Epigenetic modification connects gene regulation, cancer, sugar metabolism, ROS, carcinogenesis, and therapeutic targets. • We discuss the combined treatment of epigenetic regulator and cancer therapy. • We highlight ongoing efforts in the epigenetic modification field into cancer therapy.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2016.01.036