Dengue platelets meet Sir Arthur Conan Doyle

In this issue of Blood, Hottz et al provide compelling evidence that dengue virus (DV) induces (1) platelet synthesis of interleukin-1b (IL-1b); (2) platelet-derived IL-1b–containing microvesicles (MVs) that increase vascular permeability; and (3) DV-triggered inflammasome activation in platelets.

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Bibliographische Detailangaben
Veröffentlicht in:	Blood 2013-11, Vol.122 (20), p.3400-3401
1. Verfasser:	Bray, Paul F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Platelets - metabolism Capillary Permeability - physiology Carrier Proteins - physiology Dengue - physiopathology Endothelium, Vascular - physiopathology Female Humans Inflammasomes - physiology Interleukin-1beta - metabolism Male NLR Family, Pyrin Domain-Containing 3 Protein
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Beschreibung
Zusammenfassung:	In this issue of Blood, Hottz et al provide compelling evidence that dengue virus (DV) induces (1) platelet synthesis of interleukin-1b (IL-1b); (2) platelet-derived IL-1b–containing microvesicles (MVs) that increase vascular permeability; and (3) DV-triggered inflammasome activation in platelets.
ISSN:	0006-4971 1528-0020 1528-0020
DOI:	10.1182/blood-2013-09-526418