Immature monocytes recruited to the ischemic mouse brain differentiate into macrophages with features of alternative activation

Highlights • Ly6Chi CD43lo cells are the predominant monocytes infiltrating the ischemic tissue. • Monocytes reach the infarcted core along blood vessels from the leptomeninges. • Monocytes lose their typical blood features and differentiate to macrophages. • Infiltrated monocytes acquire features o...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2016-03, Vol.53, p.18-33
Hauptverfasser:	Miró-Mur, Francesc, Pérez-de-Puig, Isabel, Ferrer-Ferrer, Maura, Urra, Xabier, Justicia, Carles, Chamorro, Angel, Planas, Anna M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Allergy and Immunology Alternative M2 phenotype Animals Brain Ischemia - immunology Brain Ischemia - metabolism Brain Ischemia - pathology Brain Ischemia - therapy Cell Differentiation - immunology Cerebral ischemia Disease Models, Animal Leukocyte Count Macrophages Macrophages - immunology Macrophages - metabolism Macrophages - pathology Male Mice Mice, Inbred C57BL Mice, Transgenic Microglia Microglia - immunology Microglia - metabolism Microglia - pathology Monocytes Monocytes - immunology Monocytes - metabolism Monocytes - pathology Monocytes - transplantation Psychiatry Random Allocation Receptors, CCR2 - metabolism Stroke - immunology Stroke - metabolism Stroke - pathology Stroke - therapy
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Zusammenfassung:	Highlights • Ly6Chi CD43lo cells are the predominant monocytes infiltrating the ischemic tissue. • Monocytes reach the infarcted core along blood vessels from the leptomeninges. • Monocytes lose their typical blood features and differentiate to macrophages. • Infiltrated monocytes acquire features of alternatively activated macrophages.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2015.08.010