Nitric oxide in the prelimbic medial prefrontal cortex is involved in the anxiogenic-like effect induced by acute restraint stress in rats

Highlights • Restraint stress induced anxiogenic-like effect in the EPM 24 h and 7 days later. • Restraint stress increased nNOS expression in the prelimbic prefrontal cortex. • Stress-induced anxiogenic effect correlated with increased nNOS in the prelimbic. • nNOS inhibition in the prelimbic preve...

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Veröffentlicht in:	Neuroscience 2016-04, Vol.320, p.30-42
Hauptverfasser:	Vila-Verde, C, Marinho, A.L.Z, Lisboa, S.F, Guimarães, F.S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anxiety Anxiety - etiology Anxiety - metabolism elevated plus maze (EPM) Immunohistochemistry Male Neurology Nitric Oxide - metabolism nNOS Prefrontal Cortex - metabolism prelimbic medial prefrontal cortex (PL MPFC) Rats Rats, Wistar Restraint, Physical restraint-stress (RS) Stress, Psychological - metabolism
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Zusammenfassung:	Highlights • Restraint stress induced anxiogenic-like effect in the EPM 24 h and 7 days later. • Restraint stress increased nNOS expression in the prelimbic prefrontal cortex. • Stress-induced anxiogenic effect correlated with increased nNOS in the prelimbic. • nNOS inhibition in the prelimbic prevented stress-induced anxiogenic-like effect.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2016.01.040