Prostaglandin E2 -mediated upregulation of neuroexcitation and persistent tetrodotoxin-resistant Na+ currents in Ah-type trigeminal ganglion neurons isolated from adult female rats

Highlights • PGE2 increases excitability of Ah- and C-, not A-type TGNs from adult female rats. • Effect of PGE2 is cAMP- & 17β-estradiol-dependent in Ah-, rather than C-type TGNs. • PGE2 modulates the persistent TTX-R Na+ currents uniquely expressed in Ah-types. • PGE2 -mediated neuromodulation...

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Veröffentlicht in:	Neuroscience 2016-04, Vol.320, p.194-204
Hauptverfasser:	Liu, H, Duan, S.-R
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - physiology Animals Dinoprostone - metabolism Female myelinated afferent neuroexcitation Neurology Patch-Clamp Techniques persistent tetrodotoxin-resistant sodium current prostaglandin E2 Rats Rats, Sprague-Dawley Sex Characteristics Sodium Channel Blockers - pharmacology Sodium Channels - metabolism Tetrodotoxin - pharmacology Trigeminal Ganglion - metabolism trigeminal ganglion neuron Up-Regulation
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Zusammenfassung:	Highlights • PGE2 increases excitability of Ah- and C-, not A-type TGNs from adult female rats. • Effect of PGE2 is cAMP- & 17β-estradiol-dependent in Ah-, rather than C-type TGNs. • PGE2 modulates the persistent TTX-R Na+ currents uniquely expressed in Ah-types. • PGE2 -mediated neuromodulation in Ah-TGNs contributes to sex difference in migraine. • Persistent TTX-R Na+ channel is a potential target for pharmacological convention.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2016.02.008