An International Ki67 Reproducibility Study in Adrenal Cortical Carcinoma

Despite the established role of Ki67 labeling index in prognostic stratification of adrenocortical carcinomas and its recent integration into treatment flow charts, the reproducibility of the assessment method has not been determined. The aim of this study was to investigate interobserver variabilit...

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Veröffentlicht in:	The American journal of surgical pathology 2016-04, Vol.40 (4), p.569-576
Hauptverfasser:	Papathomas, Thomas G, Pucci, Eugenio, Giordano, Thomas J, Lu, Hao, Duregon, Eleonora, Volante, Marco, Papotti, Mauro, Lloyd, Ricardo V, Tischler, Arthur S, van Nederveen, Francien H, Nose, Vania, Erickson, Lori, Mete, Ozgur, Asa, Sylvia L, Turchini, John, Gill, Anthony J, Matias-Guiu, Xavier, Skordilis, Kassiani, Stephenson, Timothy J, Tissier, Frédérique, Feelders, Richard A, Smid, Marcel, Nigg, Alex, Korpershoek, Esther, van der Spek, Peter J, Dinjens, Winand N.M, Stubbs, Andrew P, de Krijger, Ronald R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adrenal Cortex Neoplasms - pathology Adrenocortical Carcinoma - pathology Adult Aged Aged, 80 and over Biomarkers, Tumor - analysis Child Female Humans Image Interpretation, Computer-Assisted Ki-67 Antigen - analysis Male Middle Aged Observer Variation Pathology, Clinical - standards Reproducibility of Results Tissue Array Analysis User-Computer Interface Young Adult
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Zusammenfassung:	Despite the established role of Ki67 labeling index in prognostic stratification of adrenocortical carcinomas and its recent integration into treatment flow charts, the reproducibility of the assessment method has not been determined. The aim of this study was to investigate interobserver variability among endocrine pathologists using a web-based virtual microscopy approach. Ki67-stained slides of 76 adrenocortical carcinomas were analyzed independently by 14 observers, each according to their method of preference including eyeballing, formal manual counting, and digital image analysis. The interobserver variation was statistically significant (P
ISSN:	0147-5185 1532-0979
DOI:	10.1097/PAS.0000000000000574