Isotope effect analyses provide evidence for an altered transition state for RNA 2'-O-transphosphorylation catalyzed by Zn(2+)
Solvent D2O and (18)O kinetic isotope effects on RNA 2'-O-transphosphorylation catalyzed by Zn(2+) demonstrate an altered transition state relative to specific base catalysis. A recent model from DFT calculations involving inner sphere coordination to the non-bridging and leaving group oxygens...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2016-03, Vol.52 (24), p.4462-4465 |
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| container_end_page | 4465 |
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| container_issue | 24 |
| container_start_page | 4462 |
| container_title | Chemical communications (Cambridge, England) |
| container_volume | 52 |
| creator | Zhang, Shuming Gu, Hong Chen, Haoyuan Strong, Emily Ollie, Edward W Kellerman, Daniel Liang, Danni Miyagi, Masaru Anderson, Vernon E Piccirilli, Joseph A York, Darrin M Harris, Michael E |
| description | Solvent D2O and (18)O kinetic isotope effects on RNA 2'-O-transphosphorylation catalyzed by Zn(2+) demonstrate an altered transition state relative to specific base catalysis. A recent model from DFT calculations involving inner sphere coordination to the non-bridging and leaving group oxygens is consistent with the data. |
| doi_str_mv | 10.1039/c5cc10212j |
| format | Article |
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| fulltext | fulltext |
| identifier | EISSN: 1364-548X |
| ispartof | Chemical communications (Cambridge, England), 2016-03, Vol.52 (24), p.4462-4465 |
| issn | 1364-548X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1773808092 |
| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Catalysis Isotopes Phosphorylation RNA - chemistry Zinc - chemistry |
| title | Isotope effect analyses provide evidence for an altered transition state for RNA 2'-O-transphosphorylation catalyzed by Zn(2+) |
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