Prediction of particle deposition in the lungs based on simple modeling of alveolar mixing

Prediction of particle deposition in the lungs based on simple modeling of alveolar mixing

Highlights • Radically simple modeling of alveolar flow and deposition. • Very good agreement with benchmark data of pulmonary deposition over wide range of breathing patterns. • Favorable comparison with more involved models. • Indirect evidence in support of the role of alveolar mixing.

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Veröffentlicht in:Respiratory physiology & neurobiology 2016-05, Vol.225, p.8-18
Hauptverfasser: Georgakakou, S, Gourgoulianis, K, Daniil, Z, Bontozoglou, V
Format: Artikel
Sprache:eng
Schlagworte:
Air
Algorithms
Alveolar mixing
Analytic modeling
Animals
Bronchi - physiology
Kinematic irreversibility
Medical Education
Models, Cardiovascular
Particle deposition
Pulmonary Alveoli - physiology
Pulmonary/Respiratory
Respiration
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Zusammenfassung:Highlights • Radically simple modeling of alveolar flow and deposition. • Very good agreement with benchmark data of pulmonary deposition over wide range of breathing patterns. • Favorable comparison with more involved models. • Indirect evidence in support of the role of alveolar mixing.
ISSN:1569-9048
1878-1519
DOI:10.1016/j.resp.2015.12.009