Time-based understanding of DLCO and DLNO

Time-based understanding of DLCO and DLNO

Highlights • A new simple physical interpretation of DLCO and DLNO is presented. • It allows for a marked reduction of the dispersion between individuals. • It shows that the conventional correction to DLCO for anaemia is erroneous. • It provides a direct determination of the capillary volume from a...

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Veröffentlicht in:Respiratory physiology & neurobiology 2016-05, Vol.225, p.48-59
Hauptverfasser: Kang, Min-Yeong, Sapoval, Bernard
Format: Artikel
Sprache:eng
Schlagworte:
Algorithms
Alveolar-capillary membrane
Blood Cells - metabolism
Capillaries - metabolism
Capillary volume
Carbon Monoxide - metabolism
Diffusion
DLCO
DLNO
Female
Haematocrit
Hemoglobins - metabolism
Heterogeneity
Humans
Male
Medical Education
Models, Cardiovascular
Nitric Oxide - metabolism
Oxygen - metabolism
Pulmonary Alveoli - metabolism
Pulmonary/Respiratory
Respiration
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Beschreibung
Zusammenfassung:Highlights • A new simple physical interpretation of DLCO and DLNO is presented. • It allows for a marked reduction of the dispersion between individuals. • It shows that the conventional correction to DLCO for anaemia is erroneous. • It provides a direct determination of the capillary volume from a single measurement of DLCO.
ISSN:1569-9048
1878-1519
DOI:10.1016/j.resp.2016.01.008