07H239-A, a New Cytotoxic Eremophilane Sesquiterpene from the Marine-Derived Xylariaceous Fungus LL-07H239

07H239-A (1), a new eremophilane sesquiterpene from a marine-derived xylariaceous fungus, was isolated, characterized, and shown to be cytotoxic toward a variety of cancer cell lines, with some selectivity for a CCRFCEM leukemia line (IC50 = 0.9 μg/mL).

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2004-09, Vol.67 (9), p.1565-1567
Hauptverfasser:	McDonald, Leonard A, Barbieri, Laurel R, Bernan, Valerie S, Janso, Jeffrey, Lassota, Peter, Carter, Guy T
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Ascomycota - chemistry Biological and medical sciences Drug Screening Assays, Antitumor Fatty Acids, Unsaturated - chemistry Fungi General pharmacology Inhibitory Concentration 50 Marine Medical sciences Molecular Structure Naphthalenes - chemistry Naphthalenes - isolation & purification Naphthalenes - pharmacology Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Sesquiterpenes - chemistry Sesquiterpenes - isolation & purification Sesquiterpenes - pharmacology Tumor Cells, Cultured Xylariaceae
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	07H239-A (1), a new eremophilane sesquiterpene from a marine-derived xylariaceous fungus, was isolated, characterized, and shown to be cytotoxic toward a variety of cancer cell lines, with some selectivity for a CCRFCEM leukemia line (IC50 = 0.9 μg/mL).
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np049924g