Early-Onset Guillain-Barré Syndrome Associated with Reactivation of Epstein-Barr Virus Infection after Nonmyeloablative Stem Cell Transplantation

We report a case of early-onset acute Guillain-Barré syndrome associated with reactivation of Epstein-Barr virus (EBV) infection after nonmyeloablative stem cell transplantation (NST). Reactivation of EBV infection preceded disease onset, and the virus load increased concomitantly with disease progr...

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Veröffentlicht in:	Clinical infectious diseases 2004-10, Vol.39 (7), p.1076-1078
Hauptverfasser:	Bitan, Menachem, Or, Reuven, Shapira, Michael Y., Mador, Nurith, Resnick, Igor B., Saleh, Niveen, Weinberger, Klaus M., Samuel, Simcha, Schechter, Esther, Slavin, Shimon, Wolf, Dana G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antilymphocyte Serum - adverse effects Biological and medical sciences Blood Brief Reports Busulfan - adverse effects Cytomegalovirus Cytomegalovirus infections Epstein Barr virus infections Epstein-Barr virus Epstein-Barr Virus Infections - complications Epstein-Barr Virus Infections - virology Guillain-Barre Syndrome - etiology Guillain-Barre Syndrome - virology Human viral diseases Humans Infections Infectious diseases Male Medical sciences Middle Aged Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Nervous system diseases Neurology Samarium - adverse effects Stem cell transplantation Stem Cell Transplantation - adverse effects Transplantation Vidarabine - adverse effects Vidarabine - analogs & derivatives Viral diseases Viral diseases of the respiratory system and ent viral diseases Virus Activation - drug effects Viruses
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Zusammenfassung:	We report a case of early-onset acute Guillain-Barré syndrome associated with reactivation of Epstein-Barr virus (EBV) infection after nonmyeloablative stem cell transplantation (NST). Reactivation of EBV infection preceded disease onset, and the virus load increased concomitantly with disease progression (doubling time, 2.7 days). This case raises concern about the expanding scope of manifestations associated with reactivation of EBV infection after NST.
ISSN:	1058-4838 1537-6591
DOI:	10.1086/424015