A model-based meta-analysis of sofosbuvir-based treatments in chronic hepatitis C patients

Highlights • This is the first model-based meta-analysis for sofosbuvir-based HCV treatments. • Significant covariates have been identified as virological response predictors. • Modelisation of virological response enables the simulation of clinical trials. • Therapy with sofosbuvir + ledipasvir is...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International journal of antimicrobial agents 2016-03, Vol.47 (3), p.184-194
Hauptverfasser:	Pérez-Pitarch, Alejandro, Guglieri-López, Beatriz, Ferriols-Lisart, Rafael, Merino-Sanjuán, Matilde
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Agents - therapeutic use Benzimidazoles - therapeutic use Drug Therapy, Combination Female Fluorenes - therapeutic use Hepacivirus - drug effects Hepatitis C virus Hepatitis C, Chronic - drug therapy Humans Imidazoles - therapeutic use Infectious Disease Male Meta-analysis Modelling Models, Theoretical Simeprevir - therapeutic use Simulation Sofosbuvir Sofosbuvir - therapeutic use
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • This is the first model-based meta-analysis for sofosbuvir-based HCV treatments. • Significant covariates have been identified as virological response predictors. • Modelisation of virological response enables the simulation of clinical trials. • Therapy with sofosbuvir + ledipasvir is probably the most effective combination.
ISSN:	0924-8579 1872-7913
DOI:	10.1016/j.ijantimicag.2015.12.008