Monitoring of treatment responses and clonal evolution of tumor cells by circulating tumor DNA of heterogeneous mutant EGFR genes in lung cancer

Highlights • EGFR ctDNA rapidly responded to an EGFR-TKI as a response predictor. • Transient ctDNA peaks of various EGFR mutants appeared during EGFR-TKI treatments. • A pretreatment EGFR -mutant tumor harbors multiple activating and T790M mutations. • T790M mutation does not necessarily confer res...

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Veröffentlicht in:	Lung cancer (Amsterdam, Netherlands) Netherlands), 2016-04, Vol.94, p.68-73
Hauptverfasser:	Imamura, Fumio, Uchida, Junji, Kukita, Yoji, Kumagai, Toru, Nishino, Kazumi, Inoue, Takako, Kimura, Madoka, Oba, Shigeyuki, Kato, Kikuya
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - therapeutic use Clonal Evolution DNA, Neoplasm - blood EGFR Evolution Exons Female Hematology, Oncology and Palliative Medicine Humans Lung cancer Lung Neoplasms - genetics Lung Neoplasms - pathology Lung Neoplasms - therapy Male Mutation Neoplasm Recurrence, Local Prognosis Protein Kinase Inhibitors - therapeutic use Pulmonary/Respiratory Receptor, Epidermal Growth Factor - genetics T790M Treatment Outcome
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Zusammenfassung:	Highlights • EGFR ctDNA rapidly responded to an EGFR-TKI as a response predictor. • Transient ctDNA peaks of various EGFR mutants appeared during EGFR-TKI treatments. • A pretreatment EGFR -mutant tumor harbors multiple activating and T790M mutations. • T790M mutation does not necessarily confer resistance phenotypes to EGFR-TKIs.
ISSN:	0169-5002 1872-8332
DOI:	10.1016/j.lungcan.2016.01.023