The metabolomic detection of lung cancer biomarkers in sputum

Highlights • We examine sputum for non-invasive metabolomic biomarkers for lung cancer. • Metabolome profiles of sputum constructed using two mass spectrometry methods. • A number of metabolites differentiated between clinical samples and healthy smokers. • Biomarkers identified which differentiated...

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Veröffentlicht in:	Lung cancer (Amsterdam, Netherlands) Netherlands), 2016-04, Vol.94, p.88-95
Hauptverfasser:	Cameron, Simon J.S, Lewis, Keir E, Beckmann, Manfred, Allison, Gordon G, Ghosal, Robin, Lewis, Paul D, Mur, Luis A.J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biomarkers Biomarkers, Tumor Cluster Analysis Female Gangliosides Gas Chromatography-Mass Spectrometry Hematology, Oncology and Palliative Medicine Humans Lung cancer Lung Neoplasms - metabolism Male Metabolome Metabolomics Metabolomics - methods Middle Aged Polyamines Pulmonary/Respiratory Risk Factors ROC Curve Spectrometry, Mass, Electrospray Ionization Sputum Sputum - metabolism
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Beschreibung
Zusammenfassung:	Highlights • We examine sputum for non-invasive metabolomic biomarkers for lung cancer. • Metabolome profiles of sputum constructed using two mass spectrometry methods. • A number of metabolites differentiated between clinical samples and healthy smokers. • Biomarkers identified which differentiated between LC positive and negative. • Sputum metabolome biomarkers have potential for a population screen for lung cancer.
ISSN:	0169-5002 1872-8332
DOI:	10.1016/j.lungcan.2016.02.006