A Randomized Multicenter Phase III Study of Single Administration of Mecapegfilgrastim (HHPG-19K), A Pegfilgrastim Biosimilar, for Prophylaxis of Chemotherapy-Induced Neutropenia in Patients With Advanced Non–Small-Cell Lung Cancer (NSCLC)

Micro-Abstract The efficacy and safety profile of mecapegfilgrastim as prophylactic use among NSCLC patients in this 2-stage study. From the double-blind stage and open-label stage, not only the efficacy comparing mecapegfilgrastim and short action G-CSF was explored, but also the exact incidence of...

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Veröffentlicht in:	Clinical lung cancer 2016-03, Vol.17 (2), p.119-127
Hauptverfasser:	Zhou, Caicun, Huang, Yunchao, Wang, Donglin, An, Changshan, Zhou, Fuxiang, Li, Yali, Chen, Gongyan, Wu, Changping, He, Jianxing, Wu, Gang, Song, Xia, Gao, Jianfei, Liu, Wei, Li, Baolan, Shi, Jianhua, Huang, Cheng, Yu, Jingrui, Feng, Jueping, Yue, Hongmei, Shi, Meiqi, Xia, Jielai
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biosimilar Pharmaceuticals - administration & dosage Carcinoma, Small Cell - complications Carcinoma, Small Cell - drug therapy Carcinoma, Small Cell - pathology China Clinical Protocols Clinical trial Efficacy Female Granulocyte Colony-Stimulating Factor - administration & dosage Granulocyte-colony stimulating factor Hematology, Oncology and Palliative Medicine Humans Long-acting PEG-rhG-CSF Lung Neoplasms - complications Lung Neoplasms - drug therapy Lung Neoplasms - pathology Male Middle Aged Myelopoiesis - drug effects Neoplasm Staging Neutropenia - etiology Neutropenia - prevention & control Neutrophils - drug effects Neutrophils - physiology Polyethylene Glycols - administration & dosage Pulmonary/Respiratory Recombinant Proteins - administration & dosage Safety Treatment Outcome
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Zusammenfassung:	Micro-Abstract The efficacy and safety profile of mecapegfilgrastim as prophylactic use among NSCLC patients in this 2-stage study. From the double-blind stage and open-label stage, not only the efficacy comparing mecapegfilgrastim and short action G-CSF was explored, but also the exact incidence of neutropenia and FN in this population was well studied.
ISSN:	1525-7304 1938-0690
DOI:	10.1016/j.cllc.2015.12.002