Response to Comment on "Long-Lived Drosophila with Overexpressed dFOXO in Adult Fat Body"

Reduced insulin/insulin-like growth factor signaling (IIS) has been shown to extend life span in Caenorhabditis elegans, Drosophila, and mice (-), and adipose tissue has been implicated in determination of life span extension by reduced IIS in these model organisms (-). We recently showed that dFOXO overexpression in adult female Drosophila fat body increases their life span, reduces their fecundity, and increases their resistance to paraquat. In contrast, Hwangbo et al. failed to find any such life-span extension, using either the wild-type or an IIS-insensitive dFOXO transgene. On the basis of analysis of mortality data, Tatar suggests that our conclusions were incorrect and that induction of dFOXO in the adult fat body did not increase life span.