Human chorionic gonadotropin, fetal sex and risk of hypertensive disorders of pregnancy: A nested case-control study

Highlights • There is a female preponderance in hypertensive pregnancy. Female fetus may has an effect on increased miR-210 expression mediated by the NF-κB pathway and contribute to placental mitochondrial dysfunction. • Increased maternal HCG levels and female fetus are two independent risk factor...

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Veröffentlicht in:Pregnancy hypertension 2016, Vol.6 (1), p.17-21
Hauptverfasser: Zheng, Qizhen, Deng, Yuqing, Zhong, Shilin, Shi, Yu
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container_title Pregnancy hypertension
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creator Zheng, Qizhen
Deng, Yuqing
Zhong, Shilin
Shi, Yu
description Highlights • There is a female preponderance in hypertensive pregnancy. Female fetus may has an effect on increased miR-210 expression mediated by the NF-κB pathway and contribute to placental mitochondrial dysfunction. • Increased maternal HCG levels and female fetus are two independent risk factors in predicting subsequent SPE at 15–20 weeks of gestation.
doi_str_mv 10.1016/j.preghy.2016.01.006
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subjects Adult
Cardiovascular
Chi-Square Distribution
Chorionic Gonadotropin - blood
Female
Gender differences
Human chorionic gonadotropin
Humans
Hypertension, Pregnancy-Induced - blood
Hypertension, Pregnancy-Induced - diagnosis
Hypertension, Pregnancy-Induced - etiology
Hypertensive pregnancy
Logistic Models
Male
Obstetrics and Gynecology
Odds Ratio
Placenta
Pre-Eclampsia - blood
Pre-Eclampsia - diagnosis
Pre-Eclampsia - etiology
Pregnancy
Pregnancy Trimester, Second
Retrospective Studies
Risk Assessment
Risk Factors
Severity of Illness Index
Sex Factors
Up-Regulation
title Human chorionic gonadotropin, fetal sex and risk of hypertensive disorders of pregnancy: A nested case-control study
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