Human chorionic gonadotropin, fetal sex and risk of hypertensive disorders of pregnancy: A nested case-control study

Highlights • There is a female preponderance in hypertensive pregnancy. Female fetus may has an effect on increased miR-210 expression mediated by the NF-κB pathway and contribute to placental mitochondrial dysfunction. • Increased maternal HCG levels and female fetus are two independent risk factor...

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Veröffentlicht in:	Pregnancy hypertension 2016, Vol.6 (1), p.17-21
Hauptverfasser:	Zheng, Qizhen, Deng, Yuqing, Zhong, Shilin, Shi, Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Cardiovascular Chi-Square Distribution Chorionic Gonadotropin - blood Female Gender differences Human chorionic gonadotropin Humans Hypertension, Pregnancy-Induced - blood Hypertension, Pregnancy-Induced - diagnosis Hypertension, Pregnancy-Induced - etiology Hypertensive pregnancy Logistic Models Male Obstetrics and Gynecology Odds Ratio Placenta Pre-Eclampsia - blood Pre-Eclampsia - diagnosis Pre-Eclampsia - etiology Pregnancy Pregnancy Trimester, Second Retrospective Studies Risk Assessment Risk Factors Severity of Illness Index Sex Factors Up-Regulation
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Zusammenfassung:	Highlights • There is a female preponderance in hypertensive pregnancy. Female fetus may has an effect on increased miR-210 expression mediated by the NF-κB pathway and contribute to placental mitochondrial dysfunction. • Increased maternal HCG levels and female fetus are two independent risk factors in predicting subsequent SPE at 15–20 weeks of gestation.
ISSN:	2210-7789 2210-7797
DOI:	10.1016/j.preghy.2016.01.006