Histopathological features of bisphosphonates related osteonecrosis of the jaw in rats with and without vitamin d supplementation

Highlights • Vitamin D affects histopathological parameters, such as the numbers of osteoblasts and osteoclasts, as well as histological and macroscopic osteonecrosis, especially in the group administered vitamin D after tooth extraction • Vitamin D diminished the suppressive effects of BPs.

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Veröffentlicht in:	Archives of oral biology 2016-05, Vol.65, p.59-65
Hauptverfasser:	Yanık, Saim, Aras, Mutan Hamdi, Erkılıç, Suna, Bozdağ, Zehra, Demir, Tuncer, Çetiner, Sedat
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Animals Bisphosphonate-Associated Osteonecrosis of the Jaw - drug therapy Bisphosphonate-Associated Osteonecrosis of the Jaw - pathology Bisphosphonates Bone Density Conservation Agents - pharmacology Dentistry Dexamethasone - pharmacology Diphosphonates - administration & dosage Diphosphonates - pharmacology Disease Models, Animal Histopathology Imidazoles - pharmacology Jaw - drug effects Jaw - pathology Jaw - surgery Jaw osteonecrosis Male Maxilla - drug effects Maxilla - pathology Maxilla - surgery Osteoblasts - drug effects Osteoblasts - pathology Osteoclasts - drug effects Osteoclasts - pathology Osteonecrosis - drug therapy Osteonecrosis - pathology Osteonecrosis - surgery Rats Rats, Wistar Tooth Extraction - adverse effects Tooth Extraction - methods Vitamin D Vitamin D - pharmacology Zoledronic acid
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Beschreibung
Zusammenfassung:	Highlights • Vitamin D affects histopathological parameters, such as the numbers of osteoblasts and osteoclasts, as well as histological and macroscopic osteonecrosis, especially in the group administered vitamin D after tooth extraction • Vitamin D diminished the suppressive effects of BPs.
ISSN:	0003-9969 1879-1506
DOI:	10.1016/j.archoralbio.2015.10.010