Nondigestible Oligosaccharides Increase Calcium Absorption and Suppress Bone Resorption in Ovariectomized Rats

Nondigestible oligosaccharides (NDO) including inulin and fructooligosaccharides (FOS) have been reported to stimulate calcium absorption. Here we report the effect of a mixture of inulin and FOS (Raftilose Synergy 1, Orafti) on calcium and bone metabolism in ovariectomized (OVX) rats. OVX rats (6 m...

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Veröffentlicht in:The Journal of nutrition 2004-02, Vol.134 (2), p.399-402
Hauptverfasser: Wastney, Meryl E., Zafar, Tasleem A., Weaver, Connie M., Zhao, Yongdong, Martin, Berdine R.
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container_start_page 399
container_title The Journal of nutrition
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creator Wastney, Meryl E.
Zafar, Tasleem A.
Weaver, Connie M.
Zhao, Yongdong
Martin, Berdine R.
description Nondigestible oligosaccharides (NDO) including inulin and fructooligosaccharides (FOS) have been reported to stimulate calcium absorption. Here we report the effect of a mixture of inulin and FOS (Raftilose Synergy 1, Orafti) on calcium and bone metabolism in ovariectomized (OVX) rats. OVX rats (6 mo old) were fed a semipurified diet for 3 mo in our animal care laboratory for stabilization after ovariectomy. They were then divided into two groups (n = 13/group) and fed either a control or a NDO-supplemented diet (55 g/kg) for 21 d. Catheters were placed in their jugular veins. After 2 d, a tracer (45Ca) was administered by gavage or i.v. and blood was sampled for up to 300 min. Urine and fecal samples were collected for 4 d after 45Ca administration. Femurs were measured for bone mineral density (BMD), breaking strength, and total calcium. Calcium absorption, femoral calcium content, BMD, and bone balance (Vbal) were significantly increased (P < 0.05) by NDO, whereas the bone resorption rate relative to the bone formation rate was significantly depressed by NDO. We conclude that feeding NDO at 5.5 g/100 g for 21 d has a positive effect on calcium absorption and retention in ovariectomized rats.
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Psychology</topic><topic>kinetics</topic><topic>nondigestible oligosaccharides</topic><topic>Oligosaccharides - administration &amp; dosage</topic><topic>Oligosaccharides - pharmacology</topic><topic>ovariectomized rats</topic><topic>Ovariectomy</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wastney, Meryl E.</creatorcontrib><creatorcontrib>Zafar, Tasleem A.</creatorcontrib><creatorcontrib>Weaver, Connie M.</creatorcontrib><creatorcontrib>Zhao, Yongdong</creatorcontrib><creatorcontrib>Martin, Berdine R.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><jtitle>The Journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wastney, Meryl E.</au><au>Zafar, Tasleem A.</au><au>Weaver, Connie M.</au><au>Zhao, Yongdong</au><au>Martin, Berdine R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nondigestible Oligosaccharides Increase Calcium Absorption and Suppress Bone Resorption in Ovariectomized Rats</atitle><jtitle>The Journal of nutrition</jtitle><addtitle>J Nutr</addtitle><date>2004-02-01</date><risdate>2004</risdate><volume>134</volume><issue>2</issue><spage>399</spage><epage>402</epage><pages>399-402</pages><issn>0022-3166</issn><eissn>1541-6100</eissn><coden>JONUAI</coden><abstract>Nondigestible oligosaccharides (NDO) including inulin and fructooligosaccharides (FOS) have been reported to stimulate calcium absorption. 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subjects Absorption
Animals
Biological and medical sciences
Bone and Bones - metabolism
Bone Resorption - metabolism
bone turnover
calcium
Calcium - metabolism
Calcium - pharmacokinetics
Digestion
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
kinetics
nondigestible oligosaccharides
Oligosaccharides - administration & dosage
Oligosaccharides - pharmacology
ovariectomized rats
Ovariectomy
Rats
Rats, Sprague-Dawley
Vertebrates: anatomy and physiology, studies on body, several organs or systems
title Nondigestible Oligosaccharides Increase Calcium Absorption and Suppress Bone Resorption in Ovariectomized Rats
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