Nondigestible Oligosaccharides Increase Calcium Absorption and Suppress Bone Resorption in Ovariectomized Rats
Nondigestible oligosaccharides (NDO) including inulin and fructooligosaccharides (FOS) have been reported to stimulate calcium absorption. Here we report the effect of a mixture of inulin and FOS (Raftilose Synergy 1, Orafti) on calcium and bone metabolism in ovariectomized (OVX) rats. OVX rats (6 m...
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description | Nondigestible oligosaccharides (NDO) including inulin and fructooligosaccharides (FOS) have been reported to stimulate calcium absorption. Here we report the effect of a mixture of inulin and FOS (Raftilose Synergy 1, Orafti) on calcium and bone metabolism in ovariectomized (OVX) rats. OVX rats (6 mo old) were fed a semipurified diet for 3 mo in our animal care laboratory for stabilization after ovariectomy. They were then divided into two groups (n = 13/group) and fed either a control or a NDO-supplemented diet (55 g/kg) for 21 d. Catheters were placed in their jugular veins. After 2 d, a tracer (45Ca) was administered by gavage or i.v. and blood was sampled for up to 300 min. Urine and fecal samples were collected for 4 d after 45Ca administration. Femurs were measured for bone mineral density (BMD), breaking strength, and total calcium. Calcium absorption, femoral calcium content, BMD, and bone balance (Vbal) were significantly increased (P < 0.05) by NDO, whereas the bone resorption rate relative to the bone formation rate was significantly depressed by NDO. We conclude that feeding NDO at 5.5 g/100 g for 21 d has a positive effect on calcium absorption and retention in ovariectomized rats. |
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Here we report the effect of a mixture of inulin and FOS (Raftilose Synergy 1, Orafti) on calcium and bone metabolism in ovariectomized (OVX) rats. OVX rats (6 mo old) were fed a semipurified diet for 3 mo in our animal care laboratory for stabilization after ovariectomy. They were then divided into two groups (n = 13/group) and fed either a control or a NDO-supplemented diet (55 g/kg) for 21 d. Catheters were placed in their jugular veins. After 2 d, a tracer (45Ca) was administered by gavage or i.v. and blood was sampled for up to 300 min. Urine and fecal samples were collected for 4 d after 45Ca administration. Femurs were measured for bone mineral density (BMD), breaking strength, and total calcium. Calcium absorption, femoral calcium content, BMD, and bone balance (Vbal) were significantly increased (P < 0.05) by NDO, whereas the bone resorption rate relative to the bone formation rate was significantly depressed by NDO. We conclude that feeding NDO at 5.5 g/100 g for 21 d has a positive effect on calcium absorption and retention in ovariectomized rats.</description><identifier>ISSN: 0022-3166</identifier><identifier>EISSN: 1541-6100</identifier><identifier>DOI: 10.1093/jn/134.2.399</identifier><identifier>PMID: 14747679</identifier><identifier>CODEN: JONUAI</identifier><language>eng</language><publisher>Bethesda, MD: Elsevier Inc</publisher><subject>Absorption ; Animals ; Biological and medical sciences ; Bone and Bones - metabolism ; Bone Resorption - metabolism ; bone turnover ; calcium ; Calcium - metabolism ; Calcium - pharmacokinetics ; Digestion ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; kinetics ; nondigestible oligosaccharides ; Oligosaccharides - administration & dosage ; Oligosaccharides - pharmacology ; ovariectomized rats ; Ovariectomy ; Rats ; Rats, Sprague-Dawley ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>The Journal of nutrition, 2004-02, Vol.134 (2), p.399-402</ispartof><rights>2004 American Society for Nutrition.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c457t-dfe0cec3dbb27c37fc9a6592d90a6e50b303659e4b9a1630d719a13ca507e01e3</citedby><cites>FETCH-LOGICAL-c457t-dfe0cec3dbb27c37fc9a6592d90a6e50b303659e4b9a1630d719a13ca507e01e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15461927$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14747679$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wastney, Meryl E.</creatorcontrib><creatorcontrib>Zafar, Tasleem A.</creatorcontrib><creatorcontrib>Weaver, Connie M.</creatorcontrib><creatorcontrib>Zhao, Yongdong</creatorcontrib><creatorcontrib>Martin, Berdine R.</creatorcontrib><title>Nondigestible Oligosaccharides Increase Calcium Absorption and Suppress Bone Resorption in Ovariectomized Rats</title><title>The Journal of nutrition</title><addtitle>J Nutr</addtitle><description>Nondigestible oligosaccharides (NDO) including inulin and fructooligosaccharides (FOS) have been reported to stimulate calcium absorption. Here we report the effect of a mixture of inulin and FOS (Raftilose Synergy 1, Orafti) on calcium and bone metabolism in ovariectomized (OVX) rats. OVX rats (6 mo old) were fed a semipurified diet for 3 mo in our animal care laboratory for stabilization after ovariectomy. They were then divided into two groups (n = 13/group) and fed either a control or a NDO-supplemented diet (55 g/kg) for 21 d. Catheters were placed in their jugular veins. After 2 d, a tracer (45Ca) was administered by gavage or i.v. and blood was sampled for up to 300 min. Urine and fecal samples were collected for 4 d after 45Ca administration. Femurs were measured for bone mineral density (BMD), breaking strength, and total calcium. Calcium absorption, femoral calcium content, BMD, and bone balance (Vbal) were significantly increased (P < 0.05) by NDO, whereas the bone resorption rate relative to the bone formation rate was significantly depressed by NDO. We conclude that feeding NDO at 5.5 g/100 g for 21 d has a positive effect on calcium absorption and retention in ovariectomized rats.</description><subject>Absorption</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bone and Bones - metabolism</subject><subject>Bone Resorption - metabolism</subject><subject>bone turnover</subject><subject>calcium</subject><subject>Calcium - metabolism</subject><subject>Calcium - pharmacokinetics</subject><subject>Digestion</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>kinetics</subject><subject>nondigestible oligosaccharides</subject><subject>Oligosaccharides - administration & dosage</subject><subject>Oligosaccharides - pharmacology</subject><subject>ovariectomized rats</subject><subject>Ovariectomy</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0022-3166</issn><issn>1541-6100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0M9vFCEUwHFiNHa7evOsXOzJ2T6GGZBj3fijSeMmrT0TBt6sbGZghJkm-tdLsxt78QSET17gS8gbBhsGil8ewiXjzabecKWekRVrG1YJBvCcrADquuJMiDNynvMBAFijPr4kZ6yRjRRSrUj4HoPze8yz7waku8HvYzbW_jTJO8z0OtiEJiPdmsH6ZaRXXY5pmn0M1ARH75ZpSpgz_RQD0lv8d-kD3T2UIWjnOPo_6OitmfMr8qI3Q8bXp3VN7r98_rH9Vt3svl5vr24q27RyrlyPYNFy13W1tFz2VhnRqtopMAJb6DjwcsamU4YJDk6ysuHWtCARGPI1uTjOnVL8tZTf6dFni8NgAsYlayYla9qSb00-HKFNMeeEvZ6SH036rRnox776EHTpq2td-hb-9jR36UZ0T_gUtID3J2CyNUOfTLA-P7m2EUzVsrh3R9ebqM0-FXN_VwPjAKqtlXgU4iiwdHrwmHS2HoNF51OJql30_3_jX6D8oI8</recordid><startdate>20040201</startdate><enddate>20040201</enddate><creator>Wastney, Meryl E.</creator><creator>Zafar, Tasleem A.</creator><creator>Weaver, Connie M.</creator><creator>Zhao, Yongdong</creator><creator>Martin, Berdine R.</creator><general>Elsevier Inc</general><general>American Society for Nutritional Sciences</general><scope>6I.</scope><scope>AAFTH</scope><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope></search><sort><creationdate>20040201</creationdate><title>Nondigestible Oligosaccharides Increase Calcium Absorption and Suppress Bone Resorption in Ovariectomized Rats</title><author>Wastney, Meryl E. ; Zafar, Tasleem A. ; Weaver, Connie M. ; Zhao, Yongdong ; Martin, Berdine R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-dfe0cec3dbb27c37fc9a6592d90a6e50b303659e4b9a1630d719a13ca507e01e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Absorption</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Bone and Bones - metabolism</topic><topic>Bone Resorption - metabolism</topic><topic>bone turnover</topic><topic>calcium</topic><topic>Calcium - metabolism</topic><topic>Calcium - pharmacokinetics</topic><topic>Digestion</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>kinetics</topic><topic>nondigestible oligosaccharides</topic><topic>Oligosaccharides - administration & dosage</topic><topic>Oligosaccharides - pharmacology</topic><topic>ovariectomized rats</topic><topic>Ovariectomy</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wastney, Meryl E.</creatorcontrib><creatorcontrib>Zafar, Tasleem A.</creatorcontrib><creatorcontrib>Weaver, Connie M.</creatorcontrib><creatorcontrib>Zhao, Yongdong</creatorcontrib><creatorcontrib>Martin, Berdine R.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><jtitle>The Journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wastney, Meryl E.</au><au>Zafar, Tasleem A.</au><au>Weaver, Connie M.</au><au>Zhao, Yongdong</au><au>Martin, Berdine R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nondigestible Oligosaccharides Increase Calcium Absorption and Suppress Bone Resorption in Ovariectomized Rats</atitle><jtitle>The Journal of nutrition</jtitle><addtitle>J Nutr</addtitle><date>2004-02-01</date><risdate>2004</risdate><volume>134</volume><issue>2</issue><spage>399</spage><epage>402</epage><pages>399-402</pages><issn>0022-3166</issn><eissn>1541-6100</eissn><coden>JONUAI</coden><abstract>Nondigestible oligosaccharides (NDO) including inulin and fructooligosaccharides (FOS) have been reported to stimulate calcium absorption. Here we report the effect of a mixture of inulin and FOS (Raftilose Synergy 1, Orafti) on calcium and bone metabolism in ovariectomized (OVX) rats. OVX rats (6 mo old) were fed a semipurified diet for 3 mo in our animal care laboratory for stabilization after ovariectomy. They were then divided into two groups (n = 13/group) and fed either a control or a NDO-supplemented diet (55 g/kg) for 21 d. Catheters were placed in their jugular veins. After 2 d, a tracer (45Ca) was administered by gavage or i.v. and blood was sampled for up to 300 min. Urine and fecal samples were collected for 4 d after 45Ca administration. Femurs were measured for bone mineral density (BMD), breaking strength, and total calcium. Calcium absorption, femoral calcium content, BMD, and bone balance (Vbal) were significantly increased (P < 0.05) by NDO, whereas the bone resorption rate relative to the bone formation rate was significantly depressed by NDO. We conclude that feeding NDO at 5.5 g/100 g for 21 d has a positive effect on calcium absorption and retention in ovariectomized rats.</abstract><cop>Bethesda, MD</cop><pub>Elsevier Inc</pub><pmid>14747679</pmid><doi>10.1093/jn/134.2.399</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Absorption Animals Biological and medical sciences Bone and Bones - metabolism Bone Resorption - metabolism bone turnover calcium Calcium - metabolism Calcium - pharmacokinetics Digestion Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology kinetics nondigestible oligosaccharides Oligosaccharides - administration & dosage Oligosaccharides - pharmacology ovariectomized rats Ovariectomy Rats Rats, Sprague-Dawley Vertebrates: anatomy and physiology, studies on body, several organs or systems |
title | Nondigestible Oligosaccharides Increase Calcium Absorption and Suppress Bone Resorption in Ovariectomized Rats |
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