Different susceptibility to polycyclic aromatic hydrocarbons (PAH)-induced DNA damage in lung tissue in male and female non-smokers

The levels of benzo(a)pyrene diol-epoxide (BPDE)-DNA adducts and polycyclic aromatic hydrocarbons (PAH) were analysed in a limited number of samples of autoptic lung tissue obtained from non-professionally exposed male (n= 13) and female (n= 12) non-smokers in an attempt to evaluate the relationship...

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Veröffentlicht in:	Biomarkers 2000, Vol.5 (6), p.447-451
Hauptverfasser:	LODOVICI, M, AKPAN, V, CASALINI, C, DOLARA, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Medical sciences Polycyclic Aromatic Hydrocarbons Bpde-DNA Adducts Human Lung Carcinogenesis Toxicology Various organic compounds
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Beschreibung
Zusammenfassung:	The levels of benzo(a)pyrene diol-epoxide (BPDE)-DNA adducts and polycyclic aromatic hydrocarbons (PAH) were analysed in a limited number of samples of autoptic lung tissue obtained from non-professionally exposed male (n= 13) and female (n= 12) non-smokers in an attempt to evaluate the relationship between gender, lung PAH levels (n= 25) and susceptibility to BPDE-DNA adduct formation (n= 18). Lung concentrations of chrysene, benzo(g,h,i)perylene and benzo(a)pyrene were significantly higher in males than in females (P
ISSN:	1354-750X 1366-5804
DOI:	10.1080/135475000750052457