Photodecomposition, photomutagenicity and photocytotoxicity of retinyl palmitate under He–Ne laser photoirradiation and its effects on photodynamic therapy of cancer cells in vitro

Highlights • Retinyl palmitate (RP) is a principal storage form of vitamin A. • No photodecomposition of RP alone under irradiation of He–Ne laser. • no mutagenicity under laser irradiation in presence or absence of HpD. • RP alone (1–100 μM) has cytotoxicity on HeLa cells. • Timing of adding RP bef...

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Veröffentlicht in:	Photodiagnosis and photodynamic therapy 2016-03, Vol.13, p.316-322
Hauptverfasser:	Ibrahim, Tarek, Rouby, Mahmoud N.El, Al-Sherbini, El-Sayed A.M, Noury, Amr H.El, Morsy, Mona E
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Survival - drug effects Chromosome Aberrations - drug effects Dose-Response Relationship, Drug HeLa Cells Hematology, Oncology and Palliative Medicine Humans Internal Medicine Laser Therapy - methods Neoplasms, Experimental - drug therapy Neoplasms, Experimental - pathology Photochemotherapy - methods Photodecomposition Photodynamic therapy (PDT) Photomutagenicity Photosensitizing Agents - administration & dosage Photosensitizing Agents - chemistry Photosensitizing Agents - radiation effects Retinyl palmitate (RP) Treatment Outcome Vitamin A Vitamin A - administration & dosage Vitamin A - analogs & derivatives Vitamin A - chemistry Vitamin A - radiation effects
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Zusammenfassung:	Highlights • Retinyl palmitate (RP) is a principal storage form of vitamin A. • No photodecomposition of RP alone under irradiation of He–Ne laser. • no mutagenicity under laser irradiation in presence or absence of HpD. • RP alone (1–100 μM) has cytotoxicity on HeLa cells. • Timing of adding RP before PDT is important since 24 h incubation enhances PDT.
ISSN:	1572-1000 1873-1597
DOI:	10.1016/j.pdpdt.2015.09.002