Efficacy of proactive long-term maintenance therapy of canine atopic dermatitis with 0.0584% hydrocortisone aceponate spray: a double-blind placebo controlled pilot study

Background Long‐term remission between flares of canine atopic dermatitis (CAD) can be difficult to achieve. Therefore, additional strategic forms of treatment are needed in order to target flare prevention. The concept of proactive therapy is recommended in the European guidelines for the treatment of human atopic eczema. Objectives To evaluate the efficacy of a proactive treatment regimen with a 0.0584% hydrocortisone aceponate (HCA) spray for CAD. Animals Client‐owned dogs with spontaneous atopic dermatitis (AD) (n = 41). Methods This pilot study was conducted as a randomised, placebo‐controlled, double‐blinded clinical trial with an end‐point of treatment failure. Dogs were treated once daily to remission, then randomly assigned to receive either the HCA spray (n = 21) or a placebo (n = 20) spray on two consecutive days each week. All dogs were on appropriate flea control. No topical or systemic anti‐inflammatory or antimicrobial agents were permitted. Intention‐to‐treat analysis was used. Results At Day 0, all the dogs were in remission or had mild AD based on their Canine Atopic Dermatitis Extent and Severity Index, version 3 (CADESI‐03) scores. The time to relapse was significantly higher in the HCA group (median 115 d; range 31–260 d) compared to the placebo group (median 33 d; range 15–61 d) (P < 0.0001). No adverse events were attributable to the HCA spray. Four dogs were lost to follow‐up and four were withdrawn after receiving prohibited medication. Conclusions and clinical importance These results indicate that proactive long‐term therapy of CAD with an HCA spray administered on two consecutive days each week is effective and well‐tolerated. Résumé Contexte Une rémission à long terme entre les crises de dermatite atopique canine (DAC) peut être difficile à obtenir. Ainsi, de nouvelles stratégies thérapeutiques sont nécessaires afin de cibler et de prévenir les crises. Le concept de thérapie proactive est recommandé en Europe pour le traitement de l'eczéma atopique de l'homme. Objectifs Evaluer l'efficacité d'un traitement proactif pour la DAC avec un spray à 0.0584% d'acéponate d'hydrocortisone (HCA). Sujets Les chiens de propriétaires atteints de dermatite atopique spontanée (AD) (n = 41). Méthodes Cette étude pilote a été menée en tant qu'essai clinique en double aveugle, contrôlée contre placebo et randomisée avec l'échec de traitement en critère d'évaluation. Les chiens ont été traité une fois par jour jusqu'à rémission puis assignés au ha