Himalensines A and B, Alkaloids from Daphniphyllum himalense
Chemical investigation into the alkaloidal constituents of the Nepalese Daphniphyllum himalense has returned two new compounds, himalensines A (1) and B (2), with unprecedented carbon skeletons. Structures of the two alkaloids have been characterized on the basis of spectroscopic methods, especially...
Gespeichert in:
| Veröffentlicht in: | Organic letters 2016-03, Vol.18 (5), p.1202-1205 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1205 |
|---|---|
| container_issue | 5 |
| container_start_page | 1202 |
| container_title | Organic letters |
| container_volume | 18 |
| creator | Zhang, Hua Shyaula, Sajan L Li, Jing-Ya Li, Jia Yue, Jian-Min |
| description | Chemical investigation into the alkaloidal constituents of the Nepalese Daphniphyllum himalense has returned two new compounds, himalensines A (1) and B (2), with unprecedented carbon skeletons. Structures of the two alkaloids have been characterized on the basis of spectroscopic methods, especially via 2D NMR data analysis. Himalensine B (2) showed marginal inhibitory activities against two kinases, PTP1B and IKK-β. |
| doi_str_mv | 10.1021/acs.orglett.6b00362 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1770873555</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1770873555</sourcerecordid><originalsourceid>FETCH-LOGICAL-a345t-42959940977147c4c581e9963cfd24bec941b7c9cc84aa69fccffcf5ddf7af9a3</originalsourceid><addsrcrecordid>eNp9kD9PwzAQxS0EolD4BEjIIwNp7cSOY4mllD9FqsQCs-U4Nk1x4mAnQ789rho6Mt3p9N67ux8ANxjNMErxXKowc_7L6r6f5SVCWZ6egAtM0yxhiKanxz5HE3AZwhYhHCf8HEzSnGNSEHIBHlZ1I61uQ93qABdQthV8vIcL-y2tq6sAjXcNfJLdpq27zc7aoYGb0aKvwJmRNujrsU7B58vzx3KVrN9f35aLdSIzQvuEpJxyThBnDBOmiKIF1pznmTJVSkqtOMElU1ypgkiZc6OUMcrQqjJMGi6zKbg75Hbe_Qw69KKpg9LWyla7IQjMGCpYRimN0uwgVd6F4LURnY_n-p3ASOyxiYhNjNjEiC26bscFQ9no6uj54xQF84Ng7966wbfx338jfwFQEnvM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1770873555</pqid></control><display><type>article</type><title>Himalensines A and B, Alkaloids from Daphniphyllum himalense</title><source>MEDLINE</source><source>ACS Publications</source><creator>Zhang, Hua ; Shyaula, Sajan L ; Li, Jing-Ya ; Li, Jia ; Yue, Jian-Min</creator><creatorcontrib>Zhang, Hua ; Shyaula, Sajan L ; Li, Jing-Ya ; Li, Jia ; Yue, Jian-Min</creatorcontrib><description>Chemical investigation into the alkaloidal constituents of the Nepalese Daphniphyllum himalense has returned two new compounds, himalensines A (1) and B (2), with unprecedented carbon skeletons. Structures of the two alkaloids have been characterized on the basis of spectroscopic methods, especially via 2D NMR data analysis. Himalensine B (2) showed marginal inhibitory activities against two kinases, PTP1B and IKK-β.</description><identifier>ISSN: 1523-7060</identifier><identifier>EISSN: 1523-7052</identifier><identifier>DOI: 10.1021/acs.orglett.6b00362</identifier><identifier>PMID: 26914844</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Alkaloids - chemistry ; Alkaloids - isolation & purification ; Amines - chemistry ; Aurora Kinase A - antagonists & inhibitors ; Chlorides - chemistry ; Cyclization ; Drugs, Chinese Herbal - chemistry ; Ferric Compounds - chemistry ; Histone Deacetylase 6 ; Histone Deacetylases - drug effects ; I-kappa B Kinase - antagonists & inhibitors ; Molecular Structure ; Nuclear Magnetic Resonance, Biomolecular ; Plant Leaves - chemistry ; Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors ; Pyridines - chemical synthesis ; Pyridines - chemistry ; Saxifragaceae - chemistry</subject><ispartof>Organic letters, 2016-03, Vol.18 (5), p.1202-1205</ispartof><rights>Copyright © 2016 American Chemical Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a345t-42959940977147c4c581e9963cfd24bec941b7c9cc84aa69fccffcf5ddf7af9a3</citedby><cites>FETCH-LOGICAL-a345t-42959940977147c4c581e9963cfd24bec941b7c9cc84aa69fccffcf5ddf7af9a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acs.orglett.6b00362$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acs.orglett.6b00362$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2765,27076,27924,27925,56738,56788</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26914844$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Hua</creatorcontrib><creatorcontrib>Shyaula, Sajan L</creatorcontrib><creatorcontrib>Li, Jing-Ya</creatorcontrib><creatorcontrib>Li, Jia</creatorcontrib><creatorcontrib>Yue, Jian-Min</creatorcontrib><title>Himalensines A and B, Alkaloids from Daphniphyllum himalense</title><title>Organic letters</title><addtitle>Org. Lett</addtitle><description>Chemical investigation into the alkaloidal constituents of the Nepalese Daphniphyllum himalense has returned two new compounds, himalensines A (1) and B (2), with unprecedented carbon skeletons. Structures of the two alkaloids have been characterized on the basis of spectroscopic methods, especially via 2D NMR data analysis. Himalensine B (2) showed marginal inhibitory activities against two kinases, PTP1B and IKK-β.</description><subject>Alkaloids - chemistry</subject><subject>Alkaloids - isolation & purification</subject><subject>Amines - chemistry</subject><subject>Aurora Kinase A - antagonists & inhibitors</subject><subject>Chlorides - chemistry</subject><subject>Cyclization</subject><subject>Drugs, Chinese Herbal - chemistry</subject><subject>Ferric Compounds - chemistry</subject><subject>Histone Deacetylase 6</subject><subject>Histone Deacetylases - drug effects</subject><subject>I-kappa B Kinase - antagonists & inhibitors</subject><subject>Molecular Structure</subject><subject>Nuclear Magnetic Resonance, Biomolecular</subject><subject>Plant Leaves - chemistry</subject><subject>Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors</subject><subject>Pyridines - chemical synthesis</subject><subject>Pyridines - chemistry</subject><subject>Saxifragaceae - chemistry</subject><issn>1523-7060</issn><issn>1523-7052</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD9PwzAQxS0EolD4BEjIIwNp7cSOY4mllD9FqsQCs-U4Nk1x4mAnQ789rho6Mt3p9N67ux8ANxjNMErxXKowc_7L6r6f5SVCWZ6egAtM0yxhiKanxz5HE3AZwhYhHCf8HEzSnGNSEHIBHlZ1I61uQ93qABdQthV8vIcL-y2tq6sAjXcNfJLdpq27zc7aoYGb0aKvwJmRNujrsU7B58vzx3KVrN9f35aLdSIzQvuEpJxyThBnDBOmiKIF1pznmTJVSkqtOMElU1ypgkiZc6OUMcrQqjJMGi6zKbg75Hbe_Qw69KKpg9LWyla7IQjMGCpYRimN0uwgVd6F4LURnY_n-p3ASOyxiYhNjNjEiC26bscFQ9no6uj54xQF84Ng7966wbfx338jfwFQEnvM</recordid><startdate>20160304</startdate><enddate>20160304</enddate><creator>Zhang, Hua</creator><creator>Shyaula, Sajan L</creator><creator>Li, Jing-Ya</creator><creator>Li, Jia</creator><creator>Yue, Jian-Min</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160304</creationdate><title>Himalensines A and B, Alkaloids from Daphniphyllum himalense</title><author>Zhang, Hua ; Shyaula, Sajan L ; Li, Jing-Ya ; Li, Jia ; Yue, Jian-Min</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a345t-42959940977147c4c581e9963cfd24bec941b7c9cc84aa69fccffcf5ddf7af9a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Alkaloids - chemistry</topic><topic>Alkaloids - isolation & purification</topic><topic>Amines - chemistry</topic><topic>Aurora Kinase A - antagonists & inhibitors</topic><topic>Chlorides - chemistry</topic><topic>Cyclization</topic><topic>Drugs, Chinese Herbal - chemistry</topic><topic>Ferric Compounds - chemistry</topic><topic>Histone Deacetylase 6</topic><topic>Histone Deacetylases - drug effects</topic><topic>I-kappa B Kinase - antagonists & inhibitors</topic><topic>Molecular Structure</topic><topic>Nuclear Magnetic Resonance, Biomolecular</topic><topic>Plant Leaves - chemistry</topic><topic>Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors</topic><topic>Pyridines - chemical synthesis</topic><topic>Pyridines - chemistry</topic><topic>Saxifragaceae - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Hua</creatorcontrib><creatorcontrib>Shyaula, Sajan L</creatorcontrib><creatorcontrib>Li, Jing-Ya</creatorcontrib><creatorcontrib>Li, Jia</creatorcontrib><creatorcontrib>Yue, Jian-Min</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Organic letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Hua</au><au>Shyaula, Sajan L</au><au>Li, Jing-Ya</au><au>Li, Jia</au><au>Yue, Jian-Min</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Himalensines A and B, Alkaloids from Daphniphyllum himalense</atitle><jtitle>Organic letters</jtitle><addtitle>Org. Lett</addtitle><date>2016-03-04</date><risdate>2016</risdate><volume>18</volume><issue>5</issue><spage>1202</spage><epage>1205</epage><pages>1202-1205</pages><issn>1523-7060</issn><eissn>1523-7052</eissn><abstract>Chemical investigation into the alkaloidal constituents of the Nepalese Daphniphyllum himalense has returned two new compounds, himalensines A (1) and B (2), with unprecedented carbon skeletons. Structures of the two alkaloids have been characterized on the basis of spectroscopic methods, especially via 2D NMR data analysis. Himalensine B (2) showed marginal inhibitory activities against two kinases, PTP1B and IKK-β.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>26914844</pmid><doi>10.1021/acs.orglett.6b00362</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1523-7060 |
| ispartof | Organic letters, 2016-03, Vol.18 (5), p.1202-1205 |
| issn | 1523-7060 1523-7052 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1770873555 |
| source | MEDLINE; ACS Publications |
| subjects | Alkaloids - chemistry Alkaloids - isolation & purification Amines - chemistry Aurora Kinase A - antagonists & inhibitors Chlorides - chemistry Cyclization Drugs, Chinese Herbal - chemistry Ferric Compounds - chemistry Histone Deacetylase 6 Histone Deacetylases - drug effects I-kappa B Kinase - antagonists & inhibitors Molecular Structure Nuclear Magnetic Resonance, Biomolecular Plant Leaves - chemistry Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors Pyridines - chemical synthesis Pyridines - chemistry Saxifragaceae - chemistry |
| title | Himalensines A and B, Alkaloids from Daphniphyllum himalense |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T23%3A09%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Himalensines%20A%20and%20B,%20Alkaloids%20from%20Daphniphyllum%20himalense&rft.jtitle=Organic%20letters&rft.au=Zhang,%20Hua&rft.date=2016-03-04&rft.volume=18&rft.issue=5&rft.spage=1202&rft.epage=1205&rft.pages=1202-1205&rft.issn=1523-7060&rft.eissn=1523-7052&rft_id=info:doi/10.1021/acs.orglett.6b00362&rft_dat=%3Cproquest_cross%3E1770873555%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1770873555&rft_id=info:pmid/26914844&rfr_iscdi=true |