Himalensines A and B, Alkaloids from Daphniphyllum himalense

Chemical investigation into the alkaloidal constituents of the Nepalese Daphniphyllum himalense has returned two new compounds, himalensines A (1) and B (2), with unprecedented carbon skeletons. Structures of the two alkaloids have been characterized on the basis of spectroscopic methods, especially...

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Veröffentlicht in:	Organic letters 2016-03, Vol.18 (5), p.1202-1205
Hauptverfasser:	Zhang, Hua, Shyaula, Sajan L, Li, Jing-Ya, Li, Jia, Yue, Jian-Min
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - chemistry Alkaloids - isolation & purification Amines - chemistry Aurora Kinase A - antagonists & inhibitors Chlorides - chemistry Cyclization Drugs, Chinese Herbal - chemistry Ferric Compounds - chemistry Histone Deacetylase 6 Histone Deacetylases - drug effects I-kappa B Kinase - antagonists & inhibitors Molecular Structure Nuclear Magnetic Resonance, Biomolecular Plant Leaves - chemistry Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors Pyridines - chemical synthesis Pyridines - chemistry Saxifragaceae - chemistry
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Beschreibung
Zusammenfassung:	Chemical investigation into the alkaloidal constituents of the Nepalese Daphniphyllum himalense has returned two new compounds, himalensines A (1) and B (2), with unprecedented carbon skeletons. Structures of the two alkaloids have been characterized on the basis of spectroscopic methods, especially via 2D NMR data analysis. Himalensine B (2) showed marginal inhibitory activities against two kinases, PTP1B and IKK-β.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/acs.orglett.6b00362