YM-215343, a Novel Antifungal Compound from Phoma sp. QN04621

Through our screening for novel antifungal compounds, YM-215343 was found in the culture extract of Phoma sp. QN04621. The structure of YM-215343 was determined by several spectroscopic experiments as a novel compound closely related to apiosporamide and fischerin. YM-215343 exhibited antifungal act...

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Veröffentlicht in:	Journal of antibiotics 2004/06/25, Vol.57(6), pp.379-382
Hauptverfasser:	SHIBAZAKI, MITSUYOSHI, TANIGUCHI, MASATOSHI, YOKOI, TAKAKO, NAGAI, KOJI, WATANABE, MASATO, SUZUKI, KENICHI, YAMAMOTO, TOMOKO
Format:	Artikel
Sprache:	eng
Schlagworte:	Antifungal Agents - chemistry Antifungal Agents - isolation & purification Antifungal Agents - pharmacology Aspergillus fumigatus Candida albicans Chromatography, Gel Cryptococcus neoformans Fermentation HeLa Cells Heterocyclic Compounds, 4 or More Rings - chemistry Heterocyclic Compounds, 4 or More Rings - isolation & purification Heterocyclic Compounds, 4 or More Rings - pharmacology Humans Inhibitory Concentration 50 Microbial Sensitivity Tests Mitosporic Fungi - chemistry Mitosporic Fungi - metabolism Naphthalenes - chemistry Naphthalenes - isolation & purification Naphthalenes - pharmacology Nuclear Magnetic Resonance, Biomolecular Phoma Plants - microbiology Pyridones - chemistry Pyridones - isolation & purification Pyridones - pharmacology Spectrometry, Mass, Fast Atom Bombardment
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Zusammenfassung:	Through our screening for novel antifungal compounds, YM-215343 was found in the culture extract of Phoma sp. QN04621. The structure of YM-215343 was determined by several spectroscopic experiments as a novel compound closely related to apiosporamide and fischerin. YM-215343 exhibited antifungal activity against the pathogenic fungi, Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus with MIC values of 2-16μg/ml. It also showed cytotoxicity against HeLa S3 cells with an IC50 of 3.4μg/ml.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.57.379