Leaching-Free Supported Gold Nanoparticles Catalyzing Cycloisomerizations under Microflow Conditions

A continuous‐flow protocol for the gold‐catalyzed cycloisomerization of sterically hindered Ugi‐adducts to spiroindolines in a packed‐bed reactor is presented. Spiroindolines with various substitution patterns are formed in good yields and with good selectivity. A detailed characterization of the ca...

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Veröffentlicht in:Advanced synthesis & catalysis 2015-10, Vol.357 (14-15), p.3141-3147
Hauptverfasser: Schröder, Felix, Erdmann, Nico, Noël, Timothy, Luque, Rafael, Van der Eycken, Erik V.
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Sprache:eng
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Zusammenfassung:A continuous‐flow protocol for the gold‐catalyzed cycloisomerization of sterically hindered Ugi‐adducts to spiroindolines in a packed‐bed reactor is presented. Spiroindolines with various substitution patterns are formed in good yields and with good selectivity. A detailed characterization of the catalyst deactivation process was conducted, whereas no metal leaching from the catalyst was detected.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201500628