Leaching-Free Supported Gold Nanoparticles Catalyzing Cycloisomerizations under Microflow Conditions
A continuous‐flow protocol for the gold‐catalyzed cycloisomerization of sterically hindered Ugi‐adducts to spiroindolines in a packed‐bed reactor is presented. Spiroindolines with various substitution patterns are formed in good yields and with good selectivity. A detailed characterization of the ca...
Gespeichert in:
Veröffentlicht in: | Advanced synthesis & catalysis 2015-10, Vol.357 (14-15), p.3141-3147 |
---|---|
Hauptverfasser: | , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | A continuous‐flow protocol for the gold‐catalyzed cycloisomerization of sterically hindered Ugi‐adducts to spiroindolines in a packed‐bed reactor is presented. Spiroindolines with various substitution patterns are formed in good yields and with good selectivity. A detailed characterization of the catalyst deactivation process was conducted, whereas no metal leaching from the catalyst was detected. |
---|---|
ISSN: | 1615-4150 1615-4169 |
DOI: | 10.1002/adsc.201500628 |