Hepatotoxicity mechanisms of isoniazid: A mini-review

Isoniazid (INH) is an antituberculosis drug associated with idiosyncratic liver injury in susceptible patients. INH‐induced hepatotoxicity remains a significant clinical problem, but the underlying mechanisms are still unclear, despite the growing evidence that INH and/or its major metabolite, hydra...

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Veröffentlicht in:	Journal of applied toxicology 2015-12, Vol.35 (12), p.1427-1432
Hauptverfasser:	Hassan, Hozeifa M., Guo, Hong-li, Yousef, Bashir A., Luyong, Zhang, Zhenzhou, Jiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Antitubercular Agents - pharmacokinetics Antitubercular Agents - toxicity Apoptosis - drug effects Chemical and Drug Induced Liver Injury - enzymology Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - pathology CYP2E1 Cytochrome P-450 Enzyme System - metabolism Cytochrome P450 Family 2 Drugs hepatotoxicity mechanisms Humans Hydrazines Injuries isoniazid Isoniazid - pharmacokinetics Isoniazid - toxicity Liver Metabolites Mitochondria, Liver - drug effects Mitochondria, Liver - pathology Oxidative Stress - drug effects Patients Pharmacology Toxicity Toxicology Tuberculosis
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Zusammenfassung:	Isoniazid (INH) is an antituberculosis drug associated with idiosyncratic liver injury in susceptible patients. INH‐induced hepatotoxicity remains a significant clinical problem, but the underlying mechanisms are still unclear, despite the growing evidence that INH and/or its major metabolite, hydrazine, play an important role in hepatotoxicity. Copyright © 2015 John Wiley & Sons, Ltd. Isoniazid (INH) is an antituberculosis drug associated with idiosyncratic liver injury in susceptible patients. INH‐induced hepatotoxicity remains a significant clinical problem, but the underlying mechanisms are still unclear, despite the growing evidence that INH and/or its major metabolite, hydrazine, play an important role in hepatotoxicity.
ISSN:	0260-437X 1099-1263
DOI:	10.1002/jat.3175