Sulfisoxazole/cyclodextrin inclusion complex incorporated in electrospun hydroxypropyl cellulose nanofibers as drug delivery system
Herein, hydroxypropyl-beta-cyclodextrin (HPβCD) inclusion complex (IC) of a hydrophobic drug, sulfisoxazole (SFS) was incorporated in hydroxypropyl cellulose (HPC) nanofibers (HPC/SFS/HPβCD-IC-NF) via electrospinning. SFS/HPβCD-IC was characterized by DSC to investigate the formation of inclusion co...
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| Veröffentlicht in: | Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2015-04, Vol.128, p.331-338 |
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| creator | Aytac, Zeynep Sen, Huseyin Sener Durgun, Engin Uyar, Tamer |
| description | Herein, hydroxypropyl-beta-cyclodextrin (HPβCD) inclusion complex (IC) of a hydrophobic drug, sulfisoxazole (SFS) was incorporated in hydroxypropyl cellulose (HPC) nanofibers (HPC/SFS/HPβCD-IC-NF) via electrospinning. SFS/HPβCD-IC was characterized by DSC to investigate the formation of inclusion complex and the stoichiometry of the complex was determined by Job's plot. Modeling studies were also performed on SFS/HPβCD-IC using ab initio technique. SEM images depicted the defect free uniform fibers and confirmed the incorporation of SFS/HPβCD-IC in nanofibers did not alter the fiber morphology. XRD analyses showed amorphous distribution of SFS/HPβCD-IC in the fiber mat. Release studies were performed in phosphate buffered saline (PBS). The results suggest higher amount of SFS released from HPC/SFS/HPβCD-IC-NF when compared to free SFS containing HPC nanofibers (HPC/SFS-NF). This was attributed to the increased solubility of SFS by inclusion complexation. Sandwich configurations were prepared by placing HPC/SFS/HPβCD-IC-NF between electrospun PCL nanofibrous mat (PCL-HPC/SFS/HPβCD-IC-NF). Consequently, PCL-HPC/SFS/HPβCD-IC-NF exhibited slower release of SFS as compared with HPC/SFS/HPβCD-IC-NF. This study may provide more efficient future strategies for developing delivery systems of hydrophobic drugs. |
| doi_str_mv | 10.1016/j.colsurfb.2015.02.019 |
| format | Article |
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SFS/HPβCD-IC was characterized by DSC to investigate the formation of inclusion complex and the stoichiometry of the complex was determined by Job's plot. Modeling studies were also performed on SFS/HPβCD-IC using ab initio technique. SEM images depicted the defect free uniform fibers and confirmed the incorporation of SFS/HPβCD-IC in nanofibers did not alter the fiber morphology. XRD analyses showed amorphous distribution of SFS/HPβCD-IC in the fiber mat. Release studies were performed in phosphate buffered saline (PBS). The results suggest higher amount of SFS released from HPC/SFS/HPβCD-IC-NF when compared to free SFS containing HPC nanofibers (HPC/SFS-NF). This was attributed to the increased solubility of SFS by inclusion complexation. Sandwich configurations were prepared by placing HPC/SFS/HPβCD-IC-NF between electrospun PCL nanofibrous mat (PCL-HPC/SFS/HPβCD-IC-NF). Consequently, PCL-HPC/SFS/HPβCD-IC-NF exhibited slower release of SFS as compared with HPC/SFS/HPβCD-IC-NF. This study may provide more efficient future strategies for developing delivery systems of hydrophobic drugs.</description><identifier>ISSN: 0927-7765</identifier><identifier>EISSN: 1873-4367</identifier><identifier>DOI: 10.1016/j.colsurfb.2015.02.019</identifier><identifier>PMID: 25769282</identifier><language>eng</language><publisher>Netherlands</publisher><subject>2-Hydroxypropyl-beta-cyclodextrin ; Anti-Infective Agents - chemistry ; beta-Cyclodextrins - chemistry ; Cellulose - analogs & derivatives ; Cellulose - chemistry ; Cellulose - ultrastructure ; Drug Carriers ; Drug delivery systems ; Drug Liberation ; Drugs ; Electrochemical Techniques ; Electrospinning ; Fibers ; Hydrophobic and Hydrophilic Interactions ; Hydroxypropyl cellulose ; Inclusion complexes ; Kinetics ; Nanofibers ; Nanofibers - chemistry ; Nanofibers - ultrastructure ; Nanostructure ; Particle Size ; Solubility ; Sulfisoxazole - chemistry</subject><ispartof>Colloids and surfaces, B, Biointerfaces, 2015-04, Vol.128, p.331-338</ispartof><rights>Copyright © 2015 Elsevier B.V. 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SFS/HPβCD-IC was characterized by DSC to investigate the formation of inclusion complex and the stoichiometry of the complex was determined by Job's plot. Modeling studies were also performed on SFS/HPβCD-IC using ab initio technique. SEM images depicted the defect free uniform fibers and confirmed the incorporation of SFS/HPβCD-IC in nanofibers did not alter the fiber morphology. XRD analyses showed amorphous distribution of SFS/HPβCD-IC in the fiber mat. Release studies were performed in phosphate buffered saline (PBS). The results suggest higher amount of SFS released from HPC/SFS/HPβCD-IC-NF when compared to free SFS containing HPC nanofibers (HPC/SFS-NF). This was attributed to the increased solubility of SFS by inclusion complexation. Sandwich configurations were prepared by placing HPC/SFS/HPβCD-IC-NF between electrospun PCL nanofibrous mat (PCL-HPC/SFS/HPβCD-IC-NF). Consequently, PCL-HPC/SFS/HPβCD-IC-NF exhibited slower release of SFS as compared with HPC/SFS/HPβCD-IC-NF. This study may provide more efficient future strategies for developing delivery systems of hydrophobic drugs.</description><subject>2-Hydroxypropyl-beta-cyclodextrin</subject><subject>Anti-Infective Agents - chemistry</subject><subject>beta-Cyclodextrins - chemistry</subject><subject>Cellulose - analogs & derivatives</subject><subject>Cellulose - chemistry</subject><subject>Cellulose - ultrastructure</subject><subject>Drug Carriers</subject><subject>Drug delivery systems</subject><subject>Drug Liberation</subject><subject>Drugs</subject><subject>Electrochemical Techniques</subject><subject>Electrospinning</subject><subject>Fibers</subject><subject>Hydrophobic and Hydrophilic Interactions</subject><subject>Hydroxypropyl cellulose</subject><subject>Inclusion complexes</subject><subject>Kinetics</subject><subject>Nanofibers</subject><subject>Nanofibers - chemistry</subject><subject>Nanofibers - ultrastructure</subject><subject>Nanostructure</subject><subject>Particle Size</subject><subject>Solubility</subject><subject>Sulfisoxazole - chemistry</subject><issn>0927-7765</issn><issn>1873-4367</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkctu1TAQQC0EopfCL1ResknqR2LHS1TxkiqxANaWH2PIlRMHO0Y33fLj5KotW7oaz-iMZzQHoStKWkqouD62LsVSc7AtI7RvCWsJVc_QgQ6SNx0X8jk6EMVkI6XoL9CrUo6EENZR-RJdsF4KxQZ2QH--1hjGkk7mLkW4dpuLycNpzeOMx9nFWsY0Y5emJcLpXEl5Sdms4PcEQwS35lSWOuOfm8_ptC05LVvEDmKsMRXAs5lTGC3kgk3BPtcf2EMcf0PecNnKCtNr9CKYWODNQ7xE3z-8_3bzqbn98vHzzbvbxvWCrk2QtvNArJKKUAnScsMtk0ZB6K3wgwm9J8EAUQGGjiq3v0UvCfc8OGs8v0Rv7__dd_xVoax6Gst5UTNDqkVTucPdoBR7AsrZQAcl5f9RIZmgvOdkR8U96vablQxBL3mcTN40JfqsVR_1o1Z91qoJ07vWvfHqYUa1E_h_bY8e-V9GQacG</recordid><startdate>20150401</startdate><enddate>20150401</enddate><creator>Aytac, Zeynep</creator><creator>Sen, Huseyin Sener</creator><creator>Durgun, Engin</creator><creator>Uyar, Tamer</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>JG9</scope><scope>L7M</scope><orcidid>https://orcid.org/0000-0002-3989-4481</orcidid></search><sort><creationdate>20150401</creationdate><title>Sulfisoxazole/cyclodextrin inclusion complex incorporated in electrospun hydroxypropyl cellulose nanofibers as drug delivery system</title><author>Aytac, Zeynep ; 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SFS/HPβCD-IC was characterized by DSC to investigate the formation of inclusion complex and the stoichiometry of the complex was determined by Job's plot. Modeling studies were also performed on SFS/HPβCD-IC using ab initio technique. SEM images depicted the defect free uniform fibers and confirmed the incorporation of SFS/HPβCD-IC in nanofibers did not alter the fiber morphology. XRD analyses showed amorphous distribution of SFS/HPβCD-IC in the fiber mat. Release studies were performed in phosphate buffered saline (PBS). The results suggest higher amount of SFS released from HPC/SFS/HPβCD-IC-NF when compared to free SFS containing HPC nanofibers (HPC/SFS-NF). This was attributed to the increased solubility of SFS by inclusion complexation. Sandwich configurations were prepared by placing HPC/SFS/HPβCD-IC-NF between electrospun PCL nanofibrous mat (PCL-HPC/SFS/HPβCD-IC-NF). Consequently, PCL-HPC/SFS/HPβCD-IC-NF exhibited slower release of SFS as compared with HPC/SFS/HPβCD-IC-NF. 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| ispartof | Colloids and surfaces, B, Biointerfaces, 2015-04, Vol.128, p.331-338 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | 2-Hydroxypropyl-beta-cyclodextrin Anti-Infective Agents - chemistry beta-Cyclodextrins - chemistry Cellulose - analogs & derivatives Cellulose - chemistry Cellulose - ultrastructure Drug Carriers Drug delivery systems Drug Liberation Drugs Electrochemical Techniques Electrospinning Fibers Hydrophobic and Hydrophilic Interactions Hydroxypropyl cellulose Inclusion complexes Kinetics Nanofibers Nanofibers - chemistry Nanofibers - ultrastructure Nanostructure Particle Size Solubility Sulfisoxazole - chemistry |
| title | Sulfisoxazole/cyclodextrin inclusion complex incorporated in electrospun hydroxypropyl cellulose nanofibers as drug delivery system |
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