Doxorubicin-loaded NaYF4 :Yb/Tm–TiO2 inorganic photosensitizers for NIR-triggered photodynamic therapy and enhanced chemotherapy in drug-resistant breast cancers

Abstract The combination therapy has exhibited important potential for the treatment of cancers, especially for drug-resistant cancers. In this report, bi-functional nanoprobes based on doxorubicin (DOX)-loaded NaYF4 :Yb/Tm–TiO2 inorganic photosensitizers (FA-NPs-DOX) were synthesized for in vivo ne...

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Veröffentlicht in:	Biomaterials 2015-07, Vol.57, p.93-106
Hauptverfasser:	Zeng, Leyong, Pan, Yuanwei, Tian, Ying, Wang, Xin, Ren, Wenzhi, Wang, Shouju, Lu, Guangming, Wu, Aiguo
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Animals Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - therapeutic use Biocompatibility Biomedical materials Breast Breast - drug effects Breast - pathology Breast cancers Breast Neoplasms - drug therapy Breast Neoplasms - pathology Cancer Chemotherapy Dentistry Doxorubicin - pharmacokinetics Doxorubicin - therapeutic use Drug Resistance, Neoplasm Enhanced chemotherapy Female Fluorides - pharmacokinetics Fluorides - therapeutic use Humans Infrared Rays MCF-7 Cells Mice, Nude Multidrug resistance Nanocomposites - therapeutic use Nanocomposites - ultrastructure Nanostructure NaYF4:Yb/Tm–TiO2 inorganic photosensitizers NIR-triggered photodynamic therapy Photochemotherapy Photosensitizing Agents - pharmacokinetics Photosensitizing Agents - therapeutic use Surgical implants Thulium - pharmacokinetics Thulium - therapeutic use Titanium - therapeutic use Titanium dioxide Ytterbium - pharmacokinetics Ytterbium - therapeutic use Yttrium - pharmacokinetics Yttrium - therapeutic use
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