Relationship between brain accumulation of manganese and aberration of hippocampal adult neurogenesis after oral exposure to manganese chloride in mice

Highlights • We examined the effect of oral Mn exposure on hippocampal neurogenesis in mice. • 800-ppm Mn dietary exposure for 56 days, but not 28 days, disrupted neurogenesis. • Reduction of Pvalb+ interneurons may be responsible for the disrupted neurogenesis. • Accumulated Mn may exert toxicity o...

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Veröffentlicht in:	Toxicology (Amsterdam) 2015-05, Vol.331, p.24-34
Hauptverfasser:	Kikuchihara, Yoh, Abe, Hajime, Tanaka, Takeshi, Kato, Mizuho, Wang, Liyun, Ikarashi, Yoshiaki, Yoshida, Toshinori, Shibutani, Makoto
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Administration, Oral Adults Animals BDNF Biomarkers - metabolism Brain Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism Chlorides - administration & dosage Chlorides - metabolism Chlorides - toxicity Emergency Exposure GABAergic interneuron GABAergic Neurons - drug effects GABAergic Neurons - metabolism GABAergic Neurons - pathology gamma-Aminobutyric Acid - metabolism Gene Expression Regulation Granular materials Hippocampal adult neurogenesis Hippocampus - drug effects Hippocampus - metabolism Hippocampus - pathology Hippocampus - physiopathology Interneurons - drug effects Interneurons - metabolism Interneurons - pathology Manganese Manganese Compounds - administration & dosage Manganese Compounds - metabolism Manganese Poisoning - etiology Manganese Poisoning - genetics Manganese Poisoning - metabolism Manganese Poisoning - pathology Manganese Poisoning - physiopathology Mice Mice, Inbred ICR Neural Stem Cells - drug effects Neural Stem Cells - metabolism Neural Stem Cells - pathology Neurogenesis - drug effects Neuronal Plasticity - drug effects Parvalbumins - genetics Parvalbumins - metabolism Promoter Regions, Genetic Proto-Oncogene Proteins c-fos - metabolism Reduction Time Factors
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Zusammenfassung:	Highlights • We examined the effect of oral Mn exposure on hippocampal neurogenesis in mice. • 800-ppm Mn dietary exposure for 56 days, but not 28 days, disrupted neurogenesis. • Reduction of Pvalb+ interneurons may be responsible for the disrupted neurogenesis. • Accumulated Mn may exert toxicity on granule cells to suppress neuronal plasticity. • Suppression of granule cell BDNF-signaling may cause Pvalb+ interneuron loss.
ISSN:	0300-483X 1879-3185
DOI:	10.1016/j.tox.2015.02.005