Microbial transformation of antimalarial terpenoids

Microbial transformation of antimalarial terpenoids

The fungal and bacterial transformation of terpenoids derived from plant essential oils, especially the sesquiterpenoid artemisinin from Artemisia annua, has produced several new candidate drugs for the treatment of malaria. Obtaining new derivatives of terpenoids, including artemisinin derivatives...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Biotechnology advances 2012-11, Vol.30 (6), p.1516-1523
Hauptverfasser: Parshikov, Igor A., Netrusov, Alexander I., Sutherland, John B.
Format: Artikel
Sprache:eng
Schlagworte:
Antimalarials - chemistry
Antimalarials - metabolism
Artemisia annua
Artemisinin
Bacteria
Bacteria - metabolism
Biotechnology
Biotransformation
chemistry
Derivatives
drugs
Essential oils
Fungi
Fungi - metabolism
Malaria
Microorganisms
Plants (organisms)
Plasmodium
Terpenes
Terpenes - chemistry
Terpenes - metabolism
Transformations
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The fungal and bacterial transformation of terpenoids derived from plant essential oils, especially the sesquiterpenoid artemisinin from Artemisia annua, has produced several new candidate drugs for the treatment of malaria. Obtaining new derivatives of terpenoids, including artemisinin derivatives with increased antimalarial activity, is an important goal of research in microbial biotechnology and medicinal chemistry.
ISSN:0734-9750
1873-1899
DOI:10.1016/j.biotechadv.2012.03.010