Tunicate-mimetic nanofibrous hydrogel adhesive with improved wet adhesion
[Display omitted] The main impediment to medical application of biomaterial-based adhesives is their poor wet adhesion strength due to hydration-induced softening and dissolution. To solve this problem, we mimicked the wound healing process found in tunicates, which use a nanofiber structure and pyr...
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| Veröffentlicht in: | Acta biomaterialia 2015-07, Vol.20, p.104-112 |
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| creator | Oh, Dongyeop X. Kim, Sangsik Lee, Dohoon Hwang, Dong Soo |
| description | [Display omitted]
The main impediment to medical application of biomaterial-based adhesives is their poor wet adhesion strength due to hydration-induced softening and dissolution. To solve this problem, we mimicked the wound healing process found in tunicates, which use a nanofiber structure and pyrogallol group to heal any damage on its tunic under sea water. We fabricated a tunicate-mimetic hydrogel adhesive based on a chitin nanofiber/gallic acid (a pyrogallol acid) composite. The pyrogallol group-mediated cross-linking and the nanofibrous structures improved the dissolution resistance and cohesion strength of the hydrogel compared to the amorphous polymeric hydrogels in wet condition. The tunicate-mimetic adhesives showed higher adhesion strength between fully hydrated skin tissues than did fibrin glue and mussel-mimetic adhesives. The tunicate mimetic hydrogels were produced at low cost from recyclable and abundant raw materials. This tunicate-mimetic adhesive system is an example of how natural materials can be engineered for biomedical applications. |
| doi_str_mv | 10.1016/j.actbio.2015.03.031 |
| format | Article |
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The main impediment to medical application of biomaterial-based adhesives is their poor wet adhesion strength due to hydration-induced softening and dissolution. To solve this problem, we mimicked the wound healing process found in tunicates, which use a nanofiber structure and pyrogallol group to heal any damage on its tunic under sea water. We fabricated a tunicate-mimetic hydrogel adhesive based on a chitin nanofiber/gallic acid (a pyrogallol acid) composite. The pyrogallol group-mediated cross-linking and the nanofibrous structures improved the dissolution resistance and cohesion strength of the hydrogel compared to the amorphous polymeric hydrogels in wet condition. The tunicate-mimetic adhesives showed higher adhesion strength between fully hydrated skin tissues than did fibrin glue and mussel-mimetic adhesives. The tunicate mimetic hydrogels were produced at low cost from recyclable and abundant raw materials. This tunicate-mimetic adhesive system is an example of how natural materials can be engineered for biomedical applications.</description><identifier>ISSN: 1742-7061</identifier><identifier>EISSN: 1878-7568</identifier><identifier>DOI: 10.1016/j.actbio.2015.03.031</identifier><identifier>PMID: 25841348</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adhesive strength ; Adhesiveness - drug effects ; Adhesives ; Adhesives - pharmacology ; Animals ; Biomimetic Materials ; Cell Death - drug effects ; Cell Line ; Cell Proliferation - drug effects ; Chitin - pharmacology ; Chitin nanofibers ; Cross-Linking Reagents - chemistry ; Dissolution ; Gels ; Hydrogel, Polyethylene Glycol Dimethacrylate - pharmacology ; Hydrogels ; Medical ; Mice ; Nanofibers - chemistry ; Nanofibers - ultrastructure ; Nanofibrous hydrogels ; Nanostructure ; Optical Imaging ; Pyrogallol ; Pyrogallol - chemistry ; Rheology - drug effects ; Skin - drug effects ; Softening ; Spectroscopy, Fourier Transform Infrared ; Strength ; Sus scrofa ; Tunicates ; Underwater adhesives ; Urochordata - chemistry ; Wettability ; Wound Healing - drug effects ; X-Ray Diffraction</subject><ispartof>Acta biomaterialia, 2015-07, Vol.20, p.104-112</ispartof><rights>2015 Acta Materialia Inc.</rights><rights>Copyright © 2015 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c535t-ad52e428503ac4c5cf8bfc679d965e6d41259117d2f87989d1768356d8f8b4233</citedby><cites>FETCH-LOGICAL-c535t-ad52e428503ac4c5cf8bfc679d965e6d41259117d2f87989d1768356d8f8b4233</cites><orcidid>0000-0002-2487-2255</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1742706115001415$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25841348$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oh, Dongyeop X.</creatorcontrib><creatorcontrib>Kim, Sangsik</creatorcontrib><creatorcontrib>Lee, Dohoon</creatorcontrib><creatorcontrib>Hwang, Dong Soo</creatorcontrib><title>Tunicate-mimetic nanofibrous hydrogel adhesive with improved wet adhesion</title><title>Acta biomaterialia</title><addtitle>Acta Biomater</addtitle><description>[Display omitted]
The main impediment to medical application of biomaterial-based adhesives is their poor wet adhesion strength due to hydration-induced softening and dissolution. To solve this problem, we mimicked the wound healing process found in tunicates, which use a nanofiber structure and pyrogallol group to heal any damage on its tunic under sea water. We fabricated a tunicate-mimetic hydrogel adhesive based on a chitin nanofiber/gallic acid (a pyrogallol acid) composite. The pyrogallol group-mediated cross-linking and the nanofibrous structures improved the dissolution resistance and cohesion strength of the hydrogel compared to the amorphous polymeric hydrogels in wet condition. The tunicate-mimetic adhesives showed higher adhesion strength between fully hydrated skin tissues than did fibrin glue and mussel-mimetic adhesives. The tunicate mimetic hydrogels were produced at low cost from recyclable and abundant raw materials. This tunicate-mimetic adhesive system is an example of how natural materials can be engineered for biomedical applications.</description><subject>Adhesive strength</subject><subject>Adhesiveness - drug effects</subject><subject>Adhesives</subject><subject>Adhesives - pharmacology</subject><subject>Animals</subject><subject>Biomimetic Materials</subject><subject>Cell Death - drug effects</subject><subject>Cell Line</subject><subject>Cell Proliferation - drug effects</subject><subject>Chitin - pharmacology</subject><subject>Chitin nanofibers</subject><subject>Cross-Linking Reagents - chemistry</subject><subject>Dissolution</subject><subject>Gels</subject><subject>Hydrogel, Polyethylene Glycol Dimethacrylate - pharmacology</subject><subject>Hydrogels</subject><subject>Medical</subject><subject>Mice</subject><subject>Nanofibers - chemistry</subject><subject>Nanofibers - ultrastructure</subject><subject>Nanofibrous hydrogels</subject><subject>Nanostructure</subject><subject>Optical Imaging</subject><subject>Pyrogallol</subject><subject>Pyrogallol - chemistry</subject><subject>Rheology - drug effects</subject><subject>Skin - drug effects</subject><subject>Softening</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>Strength</subject><subject>Sus scrofa</subject><subject>Tunicates</subject><subject>Underwater adhesives</subject><subject>Urochordata - chemistry</subject><subject>Wettability</subject><subject>Wound Healing - drug effects</subject><subject>X-Ray Diffraction</subject><issn>1742-7061</issn><issn>1878-7568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1rHDEMhk1JaT7afxDCHHOZjeVPzaVQQtoGArmkZ-O1NV0vOzOpPbsh_z4Ou-2xCQgk0CO9Qi9j58AXwMFcrRc-zMs0LQQHveCyBnxgJ4AWW6sNHtXaKtFabuCYnZay5lwiCPzEjoVGBVLhCbt92I4p-JnaIQ00p9CMfpz6tMzTtjSr55in37RpfFxRSTtqntK8atLwmKcdxeaJ5kNrGj-zj73fFPpyyGfs1_ebh-uf7d39j9vrb3dt0FLPrY9akBKoufRBBR16XPbB2C52RpOJCoTuAGwUPdoOuwjWoNQmYgWVkPKMXe731hv-bKnMbkgl0GbjR6o3O7CWC1QS34NKgcKiUG-jBrkAqPoVVXs05KmUTL17zGnw-dkBd6_WuLXbW-NerXFc1oA6dnFQ2C4Hiv-G_npRga97gOr3domyKyHRGCimTGF2cUr_V3gBG52gJQ</recordid><startdate>20150701</startdate><enddate>20150701</enddate><creator>Oh, Dongyeop X.</creator><creator>Kim, Sangsik</creator><creator>Lee, Dohoon</creator><creator>Hwang, Dong Soo</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>F28</scope><scope>JG9</scope><scope>L7M</scope><orcidid>https://orcid.org/0000-0002-2487-2255</orcidid></search><sort><creationdate>20150701</creationdate><title>Tunicate-mimetic nanofibrous hydrogel adhesive with improved wet adhesion</title><author>Oh, Dongyeop X. ; Kim, Sangsik ; Lee, Dohoon ; Hwang, Dong Soo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c535t-ad52e428503ac4c5cf8bfc679d965e6d41259117d2f87989d1768356d8f8b4233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adhesive strength</topic><topic>Adhesiveness - drug effects</topic><topic>Adhesives</topic><topic>Adhesives - pharmacology</topic><topic>Animals</topic><topic>Biomimetic Materials</topic><topic>Cell Death - drug effects</topic><topic>Cell Line</topic><topic>Cell Proliferation - drug effects</topic><topic>Chitin - pharmacology</topic><topic>Chitin nanofibers</topic><topic>Cross-Linking Reagents - chemistry</topic><topic>Dissolution</topic><topic>Gels</topic><topic>Hydrogel, Polyethylene Glycol Dimethacrylate - pharmacology</topic><topic>Hydrogels</topic><topic>Medical</topic><topic>Mice</topic><topic>Nanofibers - chemistry</topic><topic>Nanofibers - ultrastructure</topic><topic>Nanofibrous hydrogels</topic><topic>Nanostructure</topic><topic>Optical Imaging</topic><topic>Pyrogallol</topic><topic>Pyrogallol - chemistry</topic><topic>Rheology - drug effects</topic><topic>Skin - drug effects</topic><topic>Softening</topic><topic>Spectroscopy, Fourier Transform Infrared</topic><topic>Strength</topic><topic>Sus scrofa</topic><topic>Tunicates</topic><topic>Underwater adhesives</topic><topic>Urochordata - chemistry</topic><topic>Wettability</topic><topic>Wound Healing - drug effects</topic><topic>X-Ray Diffraction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oh, Dongyeop X.</creatorcontrib><creatorcontrib>Kim, Sangsik</creatorcontrib><creatorcontrib>Lee, Dohoon</creatorcontrib><creatorcontrib>Hwang, Dong Soo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Acta biomaterialia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oh, Dongyeop X.</au><au>Kim, Sangsik</au><au>Lee, Dohoon</au><au>Hwang, Dong Soo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tunicate-mimetic nanofibrous hydrogel adhesive with improved wet adhesion</atitle><jtitle>Acta biomaterialia</jtitle><addtitle>Acta Biomater</addtitle><date>2015-07-01</date><risdate>2015</risdate><volume>20</volume><spage>104</spage><epage>112</epage><pages>104-112</pages><issn>1742-7061</issn><eissn>1878-7568</eissn><abstract>[Display omitted]
The main impediment to medical application of biomaterial-based adhesives is their poor wet adhesion strength due to hydration-induced softening and dissolution. To solve this problem, we mimicked the wound healing process found in tunicates, which use a nanofiber structure and pyrogallol group to heal any damage on its tunic under sea water. We fabricated a tunicate-mimetic hydrogel adhesive based on a chitin nanofiber/gallic acid (a pyrogallol acid) composite. The pyrogallol group-mediated cross-linking and the nanofibrous structures improved the dissolution resistance and cohesion strength of the hydrogel compared to the amorphous polymeric hydrogels in wet condition. The tunicate-mimetic adhesives showed higher adhesion strength between fully hydrated skin tissues than did fibrin glue and mussel-mimetic adhesives. The tunicate mimetic hydrogels were produced at low cost from recyclable and abundant raw materials. This tunicate-mimetic adhesive system is an example of how natural materials can be engineered for biomedical applications.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>25841348</pmid><doi>10.1016/j.actbio.2015.03.031</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-2487-2255</orcidid></addata></record> |
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| subjects | Adhesive strength Adhesiveness - drug effects Adhesives Adhesives - pharmacology Animals Biomimetic Materials Cell Death - drug effects Cell Line Cell Proliferation - drug effects Chitin - pharmacology Chitin nanofibers Cross-Linking Reagents - chemistry Dissolution Gels Hydrogel, Polyethylene Glycol Dimethacrylate - pharmacology Hydrogels Medical Mice Nanofibers - chemistry Nanofibers - ultrastructure Nanofibrous hydrogels Nanostructure Optical Imaging Pyrogallol Pyrogallol - chemistry Rheology - drug effects Skin - drug effects Softening Spectroscopy, Fourier Transform Infrared Strength Sus scrofa Tunicates Underwater adhesives Urochordata - chemistry Wettability Wound Healing - drug effects X-Ray Diffraction |
| title | Tunicate-mimetic nanofibrous hydrogel adhesive with improved wet adhesion |
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