Toxicity assessment of Clostridium difficile toxins in rodent models and protection of vaccination
Highlights • Clostridium difficile binary toxins (CDTa and CDTb) are lethal in mice and hamsters. • Mice can be used as animal model to evaluate toxicity for C. difficile toxins. • Immunized mice are protected from lethality upon direct toxins injection challenge.
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| Veröffentlicht in: | Vaccine 2016-03, Vol.34 (10), p.1319-1323 |
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| container_issue | 10 |
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| container_title | Vaccine |
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| creator | Wang, Su Rustandi, Richard R Lancaster, Catherine Hong, Laura G Thiriot, David S Xie, Jinfu Secore, Susan Kristopeit, Adam Wang, Sheng-Ching Heinrichs, Jon H |
| description | Highlights • Clostridium difficile binary toxins (CDTa and CDTb) are lethal in mice and hamsters. • Mice can be used as animal model to evaluate toxicity for C. difficile toxins. • Immunized mice are protected from lethality upon direct toxins injection challenge. |
| doi_str_mv | 10.1016/j.vaccine.2015.11.026 |
| format | Article |
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All rights reserved.</rights><rights>Copyright Elsevier Limited Mar 4, 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c551t-fa484184d33757c62cfbae3d2f3afd18b06684f8b19f0aa7617b13647b220a0c3</citedby><cites>FETCH-LOGICAL-c551t-fa484184d33757c62cfbae3d2f3afd18b06684f8b19f0aa7617b13647b220a0c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1768590960?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26614590$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Su</creatorcontrib><creatorcontrib>Rustandi, Richard R</creatorcontrib><creatorcontrib>Lancaster, Catherine</creatorcontrib><creatorcontrib>Hong, Laura G</creatorcontrib><creatorcontrib>Thiriot, David S</creatorcontrib><creatorcontrib>Xie, Jinfu</creatorcontrib><creatorcontrib>Secore, Susan</creatorcontrib><creatorcontrib>Kristopeit, Adam</creatorcontrib><creatorcontrib>Wang, Sheng-Ching</creatorcontrib><creatorcontrib>Heinrichs, Jon H</creatorcontrib><title>Toxicity assessment of Clostridium difficile toxins in rodent models and protection of vaccination</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Highlights • Clostridium difficile binary toxins (CDTa and CDTb) are lethal in mice and hamsters. • Mice can be used as animal model to evaluate toxicity for C. difficile toxins. • Immunized mice are protected from lethality upon direct toxins injection challenge.</description><subject>ADP Ribose Transferases - toxicity</subject><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>Antigens</subject><subject>Bacterial Proteins - toxicity</subject><subject>Bacterial Toxins - toxicity</subject><subject>Binary toxin</subject><subject>Clostridium difficile</subject><subject>Clostridium difficile - pathogenicity</subject><subject>Clostridium difficile toxins</subject><subject>Cricetinae</subject><subject>E coli</subject><subject>Enterotoxins - toxicity</subject><subject>Experiments</subject><subject>Female</subject><subject>Immunization</subject><subject>LD50</subject><subject>Lethal Dose 50</subject><subject>Male</subject><subject>Mice</subject><subject>Mice model</subject><subject>Mice, Inbred C57BL</subject><subject>Monitoring methods</subject><subject>Pathogenesis</subject><subject>Pathogens</subject><subject>Protection</subject><subject>Toxicity</subject><subject>Toxins</subject><subject>Toxoids - 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| fulltext | fulltext |
| identifier | ISSN: 0264-410X |
| ispartof | Vaccine, 2016-03, Vol.34 (10), p.1319-1323 |
| issn | 0264-410X 1873-2518 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present); ProQuest Central UK/Ireland |
| subjects | ADP Ribose Transferases - toxicity Allergy and Immunology Animals Antigens Bacterial Proteins - toxicity Bacterial Toxins - toxicity Binary toxin Clostridium difficile Clostridium difficile - pathogenicity Clostridium difficile toxins Cricetinae E coli Enterotoxins - toxicity Experiments Female Immunization LD50 Lethal Dose 50 Male Mice Mice model Mice, Inbred C57BL Monitoring methods Pathogenesis Pathogens Protection Toxicity Toxins Toxoids - toxicity Vaccine Vaccines |
| title | Toxicity assessment of Clostridium difficile toxins in rodent models and protection of vaccination |
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