Toxicity assessment of Clostridium difficile toxins in rodent models and protection of vaccination

Highlights • Clostridium difficile binary toxins (CDTa and CDTb) are lethal in mice and hamsters. • Mice can be used as animal model to evaluate toxicity for C. difficile toxins. • Immunized mice are protected from lethality upon direct toxins injection challenge.

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Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2016-03, Vol.34 (10), p.1319-1323
Hauptverfasser:	Wang, Su, Rustandi, Richard R, Lancaster, Catherine, Hong, Laura G, Thiriot, David S, Xie, Jinfu, Secore, Susan, Kristopeit, Adam, Wang, Sheng-Ching, Heinrichs, Jon H
Format:	Artikel
Sprache:	eng
Schlagworte:	ADP Ribose Transferases - toxicity Allergy and Immunology Animals Antigens Bacterial Proteins - toxicity Bacterial Toxins - toxicity Binary toxin Clostridium difficile Clostridium difficile - pathogenicity Clostridium difficile toxins Cricetinae E coli Enterotoxins - toxicity Experiments Female Immunization LD50 Lethal Dose 50 Male Mice Mice model Mice, Inbred C57BL Monitoring methods Pathogenesis Pathogens Protection Toxicity Toxins Toxoids - toxicity Vaccine Vaccines
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Beschreibung
Zusammenfassung:	Highlights • Clostridium difficile binary toxins (CDTa and CDTb) are lethal in mice and hamsters. • Mice can be used as animal model to evaluate toxicity for C. difficile toxins. • Immunized mice are protected from lethality upon direct toxins injection challenge.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2015.11.026