Pain sensitivity following loss of cholinergic basal forebrain (CBF) neurons in the rat

Highlights • Pain sensitivity of rats was evaluated following ICV administration of 192-sap. • ICV administration of 192-sap destroyed basal forebrain cholinergic neurons. • Pain sensitivity for cold and heat stimulation was reduced, post-injection. • Cerebral and spinal cholinergic reduction/antago...

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Veröffentlicht in:	Neuroscience 2016-04, Vol.319, p.23-34
Hauptverfasser:	Vierck, C.J, Yezierski, R.P, Wiley, R.G
Format:	Artikel
Sprache:	eng
Schlagworte:	192-saporin ACh Animals Antibodies, Monoclonal - toxicity Basal Forebrain - drug effects Basal Forebrain - pathology Cholinergic Agents - toxicity cholinergic decline with aging cholinergic forebrain Cholinergic Neurons - drug effects Cholinergic Neurons - pathology Conditioning, Operant Disease Models, Animal Female Neurology pain sensitivity Pain Threshold - physiology Rats Rats, Long-Evans Ribosome Inactivating Proteins, Type 1 - toxicity stress
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Beschreibung
Zusammenfassung:	Highlights • Pain sensitivity of rats was evaluated following ICV administration of 192-sap. • ICV administration of 192-sap destroyed basal forebrain cholinergic neurons. • Pain sensitivity for cold and heat stimulation was reduced, post-injection. • Cerebral and spinal cholinergic reduction/antagonism have opposite effects. • Pain reduction was associated with stress reduction following ICV 192-sap.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2016.01.038