Tamoxifen promotes differentiation of oligodendrocyte progenitors in vitro

Highlights • Tamoxifen (TMX), 4-hydroxy-TMX (4-OHTMX) and endoxifen promote oligodendrogenesis in vitro. • TMXs promote estrogen receptor (ER)-dependent oligodendrogenesis, not reported before. • In contrast to TMX and 4-OHTMX, endoxifen induces ER-independent astrogliogenesis. • Differentiating eff...

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Veröffentlicht in:	Neuroscience 2016-04, Vol.319, p.146-154
Hauptverfasser:	Barratt, H.E, Budnick, H.C, Parra, R, Lolley, R.J, Perry, C.N, Nesic, O
Format:	Artikel
Sprache:	eng
Schlagworte:	4-hydroxy-tamoxifen Animals astrocytes Blotting, Western Cell Differentiation - drug effects endoxifen estrogen receptors Fluorescent Antibody Technique Neural Stem Cells - cytology Neural Stem Cells - drug effects Neurology oligodendrocyte progenitors Oligodendroglia - cytology Oligodendroglia - drug effects Prodrugs - pharmacology Rats tamoxifen Tamoxifen - analogs & derivatives Tamoxifen - pharmacology
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Beschreibung
Zusammenfassung:	Highlights • Tamoxifen (TMX), 4-hydroxy-TMX (4-OHTMX) and endoxifen promote oligodendrogenesis in vitro. • TMXs promote estrogen receptor (ER)-dependent oligodendrogenesis, not reported before. • In contrast to TMX and 4-OHTMX, endoxifen induces ER-independent astrogliogenesis. • Differentiating effects of TMX were achieved with clinically safe doses. • TMX is a promising candidate for the treatment of demyelinating diseases.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2016.01.026