Experimental implementation and proof of principle for a radionuclidic purity test solely based on half-life measurement

In this paper we present the results of an experimental implementation of the method (Jørgensen et al., 2012) for testing the radionuclidic purity (RNP) of F-18 compounds. The overall limitations of the experimental methods and their possible impacts on RNP detectability have been identified. We have developed an GUI application for use as an easy and automated test tool in the production procedure. The test results show that this method fully complies with the requirements in the European Pharmacopoeia (Eur. Ph.) for RNP of FDG and F-18 Sodium Fluoride. •Practical use of a new method for testing radionuclidic purity.•We have investigated limitations and possible impacts of the test.•We have tested the method on both experimental and simulated data.•We have developed a GUI in MATLAB for an easy usage.•The test complies with the requirements in Eur. Ph.