Two leptin genes and a leptin receptor gene of female chub mackerel ( Scomber japonicus ): Molecular cloning, tissue distribution and expression in different obesity indices and pubertal stages

Two leptin genes and a leptin receptor gene of female chub mackerel ( Scomber japonicus ): Molecular cloning, tissue distribution and expression in different obesity indices and pubertal stages

Highlights • Identified two subtypes of leptin showing high similarity with mammalian counterpart. • Two leptin subtypes showed different expression patterns in accordance with age. • Cloned long isoform of leptin receptor and characterized by expression in pituitary. • Hepatic lepa and brain lepr s...

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Veröffentlicht in:General and comparative endocrinology 2015-10, Vol.222, p.88-98
Hauptverfasser: Ohga, Hirofumi, Matsumori, Kojiro, Kodama, Ryoko, Kitano, Hajime, Nagano, Naoki, Yamaguchi, Akihiko, Matsuyama, Michiya
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Brackish
Cyprinidae - metabolism
Endocrinology & Metabolism
Energy metabolism
Female
Fishes - metabolism
Humans
Leptin
Leptin - genetics
Leptin - metabolism
Leptin receptor
Marine
Obesity - metabolism
Ovary - metabolism
Perciformes - metabolism
Puberty
Receptors, Leptin - genetics
Reproduction - physiology
Scomber japonicus
Scombridae
Tissue Distribution
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Zusammenfassung:Highlights • Identified two subtypes of leptin showing high similarity with mammalian counterpart. • Two leptin subtypes showed different expression patterns in accordance with age. • Cloned long isoform of leptin receptor and characterized by expression in pituitary. • Hepatic lepa and brain lepr showed weaker expressions under overfeeding condition. • Leptin and its receptor genes showed no variations in different maturational stages.
ISSN:0016-6480
1095-6840
DOI:10.1016/j.ygcen.2015.06.002