Novel ISCOMs from Quillaja brasiliensis saponins induce mucosal and systemic antibody production, T-cell responses and improved antigen uptake
Highlights • Novel ISCOMs formulated with Quillaja brasiliensis saponins. • IQB90 were efficiently uptaken by murine bone marrow-derived dendritic cells. • Subcutaneously inoculated IQB-90 induced strong serum antibody responses. • Intranasally delivered IQB-90 elicited serum IgG and IgG1 and mucosa...
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| Veröffentlicht in: | Vaccine 2016-02, Vol.34 (9), p.1162-1171 |
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| container_title | Vaccine |
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| creator | Cibulski, Samuel Paulo Mourglia-Ettlin, Gustavo Teixeira, Thais Fumaco Quirici, Lenora Roehe, Paulo Michel Ferreira, Fernando Silveira, Fernando |
| description | Highlights • Novel ISCOMs formulated with Quillaja brasiliensis saponins. • IQB90 were efficiently uptaken by murine bone marrow-derived dendritic cells. • Subcutaneously inoculated IQB-90 induced strong serum antibody responses. • Intranasally delivered IQB-90 elicited serum IgG and IgG1 and mucosal IgA. • IQB-90 is a promising alternative to classic ISCOMs as vaccine adjuvants. |
| doi_str_mv | 10.1016/j.vaccine.2016.01.029 |
| format | Article |
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chemistry</subject><subject>Adjuvants, Immunologic - pharmacology</subject><subject>Administration, Intranasal</subject><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>Antigens</subject><subject>Aqueous solutions</subject><subject>Bone marrow</subject><subject>Bone Marrow Cells - immunology</subject><subject>Cercopithecus aethiops</subject><subject>Conflicts of interest</subject><subject>Cytokines - immunology</subject><subject>Cytotoxicity</subject><subject>Dendritic Cells - immunology</subject><subject>Female</subject><subject>Humoral and cell responses</subject><subject>Immunity, Cellular</subject><subject>Immunity, Humoral</subject><subject>Immunity, Mucosal</subject><subject>Immunoglobulin A - immunology</subject><subject>Immunoglobulin G - blood</subject><subject>Immunoglobulin G - immunology</subject><subject>Infectious diseases</subject><subject>Injections, Subcutaneous</subject><subject>Intranasally delivered</subject><subject>ISCOM</subject><subject>ISCOMs - 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| subjects | Adjuvants, Immunologic - chemistry Adjuvants, Immunologic - pharmacology Administration, Intranasal Allergy and Immunology Animals Antigens Aqueous solutions Bone marrow Bone Marrow Cells - immunology Cercopithecus aethiops Conflicts of interest Cytokines - immunology Cytotoxicity Dendritic Cells - immunology Female Humoral and cell responses Immunity, Cellular Immunity, Humoral Immunity, Mucosal Immunoglobulin A - immunology Immunoglobulin G - blood Immunoglobulin G - immunology Infectious diseases Injections, Subcutaneous Intranasally delivered ISCOM ISCOMs - chemistry ISCOMs - pharmacology Lymphocyte Activation Male Mice Mice, Inbred C57BL Nanoparticles - chemistry Proteins Quillaja Quillaja - chemistry Quillaja brasiliensis Quillaja saponaria Quillaja Saponins - chemistry Quillaja Saponins - pharmacology Rabbits Saponins - chemistry Saponins - pharmacology Subcutaneously T-Lymphocytes, Cytotoxic - immunology Toxicity Uptake Vaccines Vero Cells Veterinary medicine |
| title | Novel ISCOMs from Quillaja brasiliensis saponins induce mucosal and systemic antibody production, T-cell responses and improved antigen uptake |
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