Novel ISCOMs from Quillaja brasiliensis saponins induce mucosal and systemic antibody production, T-cell responses and improved antigen uptake

Highlights • Novel ISCOMs formulated with Quillaja brasiliensis saponins. • IQB90 were efficiently uptaken by murine bone marrow-derived dendritic cells. • Subcutaneously inoculated IQB-90 induced strong serum antibody responses. • Intranasally delivered IQB-90 elicited serum IgG and IgG1 and mucosa...

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Veröffentlicht in:	Vaccine 2016-02, Vol.34 (9), p.1162-1171
Hauptverfasser:	Cibulski, Samuel Paulo, Mourglia-Ettlin, Gustavo, Teixeira, Thais Fumaco, Quirici, Lenora, Roehe, Paulo Michel, Ferreira, Fernando, Silveira, Fernando
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - chemistry Adjuvants, Immunologic - pharmacology Administration, Intranasal Allergy and Immunology Animals Antigens Aqueous solutions Bone marrow Bone Marrow Cells - immunology Cercopithecus aethiops Conflicts of interest Cytokines - immunology Cytotoxicity Dendritic Cells - immunology Female Humoral and cell responses Immunity, Cellular Immunity, Humoral Immunity, Mucosal Immunoglobulin A - immunology Immunoglobulin G - blood Immunoglobulin G - immunology Infectious diseases Injections, Subcutaneous Intranasally delivered ISCOM ISCOMs - chemistry ISCOMs - pharmacology Lymphocyte Activation Male Mice Mice, Inbred C57BL Nanoparticles - chemistry Proteins Quillaja Quillaja - chemistry Quillaja brasiliensis Quillaja saponaria Quillaja Saponins - chemistry Quillaja Saponins - pharmacology Rabbits Saponins - chemistry Saponins - pharmacology Subcutaneously T-Lymphocytes, Cytotoxic - immunology Toxicity Uptake Vaccines Vero Cells Veterinary medicine
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Beschreibung
Zusammenfassung:	Highlights • Novel ISCOMs formulated with Quillaja brasiliensis saponins. • IQB90 were efficiently uptaken by murine bone marrow-derived dendritic cells. • Subcutaneously inoculated IQB-90 induced strong serum antibody responses. • Intranasally delivered IQB-90 elicited serum IgG and IgG1 and mucosal IgA. • IQB-90 is a promising alternative to classic ISCOMs as vaccine adjuvants.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2016.01.029