Recombinant lipidated dengue-3 envelope protein domain III stimulates broad immune responses in mice

Recombinant lipidated dengue-3 envelope protein domain III stimulates broad immune responses in mice

Highlights • Lipidated dengue-3 envelope protein domain III can induce broad profiles of cellular and humoral immune responses. • Lipidated dengue-3 envelope protein domain III stimulates neutralizing antibody responses without exogenous adjuvants. • Viremia levels are reduced in mice immunized with...

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Veröffentlicht in:Vaccine 2016-02, Vol.34 (8), p.1054-1061
Hauptverfasser: Chiang, Chen-Yi, Liu, Shih-Jen, Hsieh, Chun-Hsiang, Chen, Mei-Yu, Tsai, Jy-Ping, Liu, Hsueh-Hung, Chen, I.-Hua, Chong, Pele, Leng, Chih-Hsiang, Chen, Hsin-Wei
Format: Artikel
Sprache:eng
Schlagworte:
Adjuvants, Immunologic - pharmacology
Allergy and Immunology
Aluminum
Animals
Antibodies, Neutralizing - blood
Antibodies, Viral - blood
Antigens
Cloning
Cytokines
Cytokines - immunology
Dendritic Cells - immunology
Dengue - prevention & control
Dengue fever
Dengue Vaccines - immunology
Dengue Virus
Envelope protein domain III
Escherichia
Female
Immune system
Immunity, Cellular
Immunity, Humoral
Immunization
Immunoglobulin G - blood
Immunoglobulins
Infections
Laboratory animals
Lipids - chemistry
Lipoprotein
Medical research
Mice
Mice, Inbred BALB C
Pattern recognition
Proteins
Recombinant Proteins - immunology
Research centers
Studies
T-Lymphocytes - immunology
Vaccine
Vaccines
Vector-borne diseases
Viral Envelope Proteins - immunology
Viral infections
Viremia - prevention & control
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Zusammenfassung:Highlights • Lipidated dengue-3 envelope protein domain III can induce broad profiles of cellular and humoral immune responses. • Lipidated dengue-3 envelope protein domain III stimulates neutralizing antibody responses without exogenous adjuvants. • Viremia levels are reduced in mice immunized with lipidated dengue-3 envelope protein domain III.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2016.01.009