The impacts of diabetes in pregnancy on hippocampal synaptogenesis in rat neonates
Highlights • A down-regulation in hippocampal SYN expression in the pups due to maternal diabetes. • A decrease in the localization of SYN in various subfields of developing hippocampus. • Known mechanisms by which maternal diabetes affects developing CNS are discussed. • Mechanisms that rely on the...
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| Veröffentlicht in: | Neuroscience 2016-03, Vol.318, p.122-133 |
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| container_title | Neuroscience |
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| creator | Vafaei-Nezhad, S Hami, J Sadeghi, A Ghaemi, K Hosseini, M Abedini, M.R Haghir, H |
| description | Highlights • A down-regulation in hippocampal SYN expression in the pups due to maternal diabetes. • A decrease in the localization of SYN in various subfields of developing hippocampus. • Known mechanisms by which maternal diabetes affects developing CNS are discussed. • Mechanisms that rely on the changes in SYP expression in diabetic mothers are proposed. |
| doi_str_mv | 10.1016/j.neuroscience.2016.01.025 |
| format | Article |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Animals, Newborn Blood Glucose - metabolism Female hippocampus Hippocampus - drug effects Hippocampus - metabolism Hippocampus - physiopathology Insulin - pharmacology maternal diabetes Maze Learning - drug effects Maze Learning - physiology Memory - physiology Neurogenesis - physiology Neurology Pregnancy Pregnancy in Diabetics - metabolism Prenatal Exposure Delayed Effects - physiopathology rat newborn Rats, Wistar Synapses - metabolism synaptogenesis synaptophysin Synaptophysin - metabolism |
| title | The impacts of diabetes in pregnancy on hippocampal synaptogenesis in rat neonates |
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