The impacts of diabetes in pregnancy on hippocampal synaptogenesis in rat neonates

Highlights • A down-regulation in hippocampal SYN expression in the pups due to maternal diabetes. • A decrease in the localization of SYN in various subfields of developing hippocampus. • Known mechanisms by which maternal diabetes affects developing CNS are discussed. • Mechanisms that rely on the...

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Veröffentlicht in:	Neuroscience 2016-03, Vol.318, p.122-133
Hauptverfasser:	Vafaei-Nezhad, S, Hami, J, Sadeghi, A, Ghaemi, K, Hosseini, M, Abedini, M.R, Haghir, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Blood Glucose - metabolism Female hippocampus Hippocampus - drug effects Hippocampus - metabolism Hippocampus - physiopathology Insulin - pharmacology maternal diabetes Maze Learning - drug effects Maze Learning - physiology Memory - physiology Neurogenesis - physiology Neurology Pregnancy Pregnancy in Diabetics - metabolism Prenatal Exposure Delayed Effects - physiopathology rat newborn Rats, Wistar Synapses - metabolism synaptogenesis synaptophysin Synaptophysin - metabolism
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Beschreibung
Zusammenfassung:	Highlights • A down-regulation in hippocampal SYN expression in the pups due to maternal diabetes. • A decrease in the localization of SYN in various subfields of developing hippocampus. • Known mechanisms by which maternal diabetes affects developing CNS are discussed. • Mechanisms that rely on the changes in SYP expression in diabetic mothers are proposed.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2016.01.025