Hypothalamic feedforward inhibition of thalamocortical network controls arousal and consciousness

The authors identify a new arousal circuit in the mammalian brain. They provide correlative and optogenetic evidence indicating that a subset of hypothalamic cells drive awakening from non-rapid eye movement (slow-wave) sleep and emergence from anesthesia by exerting a strong inhibitory tone onto re...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature neuroscience 2016-02, Vol.19 (2), p.290-298
Hauptverfasser:	Herrera, Carolina Gutierrez, Cadavieco, Marta Carus, Jego, Sonia, Ponomarenko, Alexey, Korotkova, Tatiana, Adamantidis, Antoine
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378/1385/1877 631/378/1385/2641 631/378/1488/1562 631/378/2613/1838 631/378/3920 64/60 Analysis Anesthesia Animal Genetics and Genomics Animals Arousal (Psychophysiology) Arousal - physiology Behavior, Animal - physiology Behavioral Sciences Biological Techniques Biomedicine Cerebral Cortex - physiology Consciousness Consciousness - physiology Delta Rhythm Electroencephalography Female gamma-Aminobutyric Acid - physiology Hypothalamus Hypothalamus - physiology Identification and classification In Vitro Techniques Male Mice Mice, Inbred C57BL Nerve Net - physiology Neural circuitry Neurobiology Neurons Neurosciences Optogenetics Physiological aspects Sleep Sleep - physiology Sleep, REM - physiology Thalamus - physiology Vesicular Inhibitory Amino Acid Transport Proteins - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The authors identify a new arousal circuit in the mammalian brain. They provide correlative and optogenetic evidence indicating that a subset of hypothalamic cells drive awakening from non-rapid eye movement (slow-wave) sleep and emergence from anesthesia by exerting a strong inhibitory tone onto reticular thalamic neurons. During non-rapid eye movement (NREM) sleep, synchronous synaptic activity in the thalamocortical network generates predominantly low-frequency oscillations (
ISSN:	1097-6256 1546-1726
DOI:	10.1038/nn.4209