Postnatal development and sensory experience synergistically underlie the excitatory/inhibitory features of hippocampal neural circuits: Glutamatergic and GABAergic neurotransmission

Highlights • Basic and tetanized EPSP were recorded in hippocampus of normal and dark-reared rats. • Protein and mRNA expression of glutamatergic and GABAergic receptors were evaluated. • Dark rearing (DR) increased the size of EPSPs but decreased the degree of their potentiation. • Sensory experien...

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Veröffentlicht in:	Neuroscience 2016-03, Vol.318, p.230-243
Hauptverfasser:	Talaei, S.A, Azami, A, Salami, M
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - pharmacology Animals Animals, Newborn Excitatory Postsynaptic Potentials - drug effects excitatory/inhibitory neurotransmission GABAergic Neurons - drug effects hippocampus Hippocampus - drug effects Male Neurology Neuronal Plasticity - drug effects Neuronal Plasticity - physiology postnatal development Pyramidal Cells - drug effects Pyramidal Cells - physiology rat Rats, Wistar Receptors, AMPA - metabolism synaptic plasticity Synaptic Transmission - drug effects Synaptic Transmission - physiology visual experience
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Zusammenfassung:	Highlights • Basic and tetanized EPSP were recorded in hippocampus of normal and dark-reared rats. • Protein and mRNA expression of glutamatergic and GABAergic receptors were evaluated. • Dark rearing (DR) increased the size of EPSPs but decreased the degree of their potentiation. • Sensory experience adjusts synaptic plasticity and might affect balance of excitation/inhibition.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2016.01.024