Repression of TIF1γ by SOX2 promotes TGF-β-induced epithelial–mesenchymal transition in non-small-cell lung cancer

TIF1γ is a novel regulator of transforming growth factor (TGF)-β/Smad signaling. Our previous studies show that dysregulated expression of transcriptional intermediary factor 1 γ (TIF1γ) and abnormal TGF-β/Smad signaling are implicated in non-small-cell lung cancer (NSCLC) separately. However, how T...

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Veröffentlicht in:	Oncogene 2016-02, Vol.35 (7), p.867-877
Hauptverfasser:	Wang, L, Yang, H, Lei, Z, Zhao, J, Chen, Y, Chen, P, Li, C, Zeng, Y, Liu, Z, Liu, X, Zhang, H-T
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/109 13/44 13/89 38/77 38/90 631/67/1612/1350 64/60 82/80 96/95 Animals Apoptosis Blotting, Western Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Cell Biology Cell Line, Tumor Chromatin Immunoprecipitation Electrophoretic Mobility Shift Assay Epithelial-Mesenchymal Transition Female Fluorescent Antibody Technique Gene expression Gene Expression Regulation, Neoplastic - physiology Gene Knockdown Techniques Gene silencing Heterografts Human Genetics Humans Internal Medicine Lung cancer Lung Neoplasms - metabolism Lung Neoplasms - pathology Medicine Medicine & Public Health Mesenchyme Metastases Metastasis Mice Mice, Nude Non-small cell lung carcinoma Oncology original-article Proteins Real-Time Polymerase Chain Reaction RNA, Small Interfering Signal Transduction - physiology Smad protein Smad4 protein Small cell lung carcinoma Sox2 protein SOXB1 Transcription Factors - metabolism Transcription Factors - metabolism Transcription, Genetic - physiology Transfection Transforming Growth Factor beta - metabolism Transforming growth factor-b
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