Positive effects of bisphosphonates on bone and muscle in a mouse model of Duchenne muscular dystrophy

Highlights • We treated growing Mdx mice with pamidronate for 2 weeks. • Pamidronate treatment increased cortical bone mineral density and bone strength. • Pamidronate treatment suppressed trabecular bone remodeling. • Pamidronate treatment improved muscle strength and suppressed serum and muscle cr...

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Veröffentlicht in:	Neuromuscular disorders : NMD 2016-01, Vol.26 (1), p.73-84
Hauptverfasser:	Yoon, Sung-Hee, Sugamori, Kim S, Grynpas, Marc D, Mitchell, Jane
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Biomechanical Phenomena - drug effects Biomechanical Phenomena - genetics Bisphosphonates Body Weight - drug effects Body Weight - genetics Bone and Bones - drug effects Bone and Bones - pathology Bone and Bones - physiology Bone Density - drug effects Bone Density Conservation Agents - pharmacology Bone Density Conservation Agents - therapeutic use Bone mineral density Bone strength Creatine kinase Creatine Kinase - blood Diphosphonates - pharmacology Diphosphonates - therapeutic use Disease Models, Animal Duchenne muscular dystrophy Fluoresceins - metabolism Mesenchymal Stromal Cells - drug effects Mice Mice, Inbred C57BL Mice, Inbred mdx Muscle Strength - drug effects Muscle Strength - genetics Muscle, Skeletal - drug effects Muscular Dystrophy, Animal - blood Muscular Dystrophy, Animal - drug therapy Muscular Dystrophy, Animal - genetics Muscular Dystrophy, Animal - pathology Neurology RNA, Messenger - metabolism
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Zusammenfassung:	Highlights • We treated growing Mdx mice with pamidronate for 2 weeks. • Pamidronate treatment increased cortical bone mineral density and bone strength. • Pamidronate treatment suppressed trabecular bone remodeling. • Pamidronate treatment improved muscle strength and suppressed serum and muscle creatine kinase levels.
ISSN:	0960-8966 1873-2364
DOI:	10.1016/j.nmd.2015.09.015