NuMA Phosphorylation by Aurora-A Orchestrates Spindle Orientation

Spindle positioning is essential for tissue morphogenesis and homeostasis. The signaling network synchronizing spindle placement with mitotic progression relies on timely recruitment at the cell cortex of NuMA:LGN:Gαi complexes, in which NuMA acts as a receptor for the microtubule motor Dynein. To s...

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Veröffentlicht in:	Current biology 2016-02, Vol.26 (4), p.458-469
Hauptverfasser:	Gallini, Sara, Carminati, Manuel, De Mattia, Fabiola, Pirovano, Laura, Martini, Emanuele, Oldani, Amanda, Asteriti, Italia Anna, Guarguaglini, Giulia, Mapelli, Marina
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Nuclear - genetics Antigens, Nuclear - metabolism Aurora Kinase A - genetics Aurora Kinase A - metabolism Cell Cycle Dyneins - metabolism HeLa Cells Humans Metaphase Nuclear Matrix-Associated Proteins - genetics Nuclear Matrix-Associated Proteins - metabolism Phosphorylation Protein Binding Spindle Apparatus - metabolism
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